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Correlation between baseline retinal microstructures in spectral-domain optic coherence tomography and need for early intervention in central serous chorioretinopathy
  1. Wei-Yu Lai1,
  2. Cheui-Lien Tseng1,
  3. Tsung-Tien Wu1,2,
  4. Huey-Shyan Lin3,
  5. Shwu-Jiuan Sheu1,2
  1. 1 Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
  2. 2 Department of Ophthalmology, National Yang-Ming University, Taipei, Taiwan
  3. 3 Department of Health-Business Administration, Fooyin University, Kaohsiung, Taiwan
  1. Correspondence to Dr Shwu-Jiuan Sheu; sjiuansheu{at}


Purpose To investigate the association between baseline retinal microstructures observed with spectral-domain optical coherence tomography (OCT) and the need for early intervention in central serous chorioretinopathy (CSC).

Methods Cases of acute CSC from July 2011 to December 2014 were retrospectively reviewed. OCT images were further classified using six parameters: foveal serous retinal detachment; pigment epithelial detachment; fibrinous exudates in the subretinal space; retinal pigment epithelium bumps; thickened outer retinal layer and hyper-reflective dots in the intraretinal and/or subretinal layer. Correlation among these parameters and the need for intervention was analysed. Receiver operating characteristic (ROC) curves were performed to identify the optimal number of parameters for prediction.

Results A total of 47 eyes from 47 patients were included. Among these, 25 eyes required treatment. The presence of subretinal hyper-reflective dots was the only OCT factor having significant association with the need for intervention. An ROC curve analysis revealed that the optimal cut-off value (Youden index) was achieved when combining subretinal hyper-reflective dots with aged ≥50 years and female sex for analysis (area under the curve, 0.735; Youden index: 0.425).

Conclusion The presence of subretinal/intraretinal hyper-reflective dots observed with OCT, female and aged ≥50 years might help predict the need for early intervention in acute CSC.

  • central serous chorioretinopathy
  • intervention
  • optical coherence tomography (OCT)

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  • Contributors WYL participated in acquisition, analysis and interpretation of data and also drafted the manuscript. TTW participated in the acquisition of data. CLT and HSL participated in the analysis and interpretation of data. SJS conceived of and coordinated the study, and also revised critically the manuscript. All authors read and approved the final manuscript.

  • Competing interests None declared.

  • Ethics approval Ethical approval was obtained from the local ethics committee of Kaohsiung Veterans General Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All data from the study are being published.

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