Topic Collection

Neeru A. Vallabh Department of Eye and Vision Science, University of Liverpool, UK orcid.org/0000-0002-0109-4112

Carl Sheridan Department of Eye and Vision Science, University of Liverpool, UK orcid.org/0000-0003-0100-9587

Colin E. Willoughby Biomedical Sciences Research Institute, Ulster University, UK orcid.org/0000-0002-1246-4166

The trabecular meshwork is a vital ocular structure that regulates intra-ocular pressure (IOP). Given IOP is currently the only modifiable risk factor for glaucoma, there is intense interest in the pathophysiology of IOP and the role of the trabecular meshwork in health and disease. Pharmacological, gene and cellular therapies at various levels of technology readiness targeting the trabecular meshwork are currently under investigation. The emergence of minimally invasive glaucoma surgeries (MIGS) has catalysed new interest in the physiology of the trabecular meshwork in health and disease. This special collection aims to collate a series of papers, both review articles and original research, in all aspects of the trabecular meshwork in health and disease. This can include (but not limited to):

• Molecular and cell biology of the trabecular meshwork including mechanobiology, high-resolution imaging and physiological assessments
• Therapeutic approaches to restore trabecular meshwork function
• Novel therapies, drug delivery and cell enhancement/replacement approaches and model systems
• Understanding the mechanism of action of MIGS including device selection, impact on the trabecular meshwork and surgical outcomes

Articles that span the complete basic, translational and clinical science of the trabecular meshwork in health and disease, are also welcome.

Please see the instructions for authors for submission requirements for each article type. To submit your article, please follow these instructions and select ‘Trabecular Meshwork in Health and Disease’ as the Topic Collection. All submitted articles will be subject to the journal's normal peer review process. The Editor in Chief is responsible for the content of this Topic Collection. Guest Editors will manage peer review, invite reviewers and make a recommendation, but the final decision on all manuscripts will be made by the Editor-in-Chief. Articles accepted for publication will be published upon acceptance. Visit our author hub for more information regarding the publication process for topic collections. Authors submitting to this Topic Collection are entitled to a 25% discount on the Article Processing Charge. Discount is available upon request to info.bmjophth@bmj.com. For any inquiries regarding this topic collection, please contact topic.collections@bmj.com. Key words: Trabecular meshwork, glaucoma. Schlemm’s canal, pharmacology, ophthalmology, cell biology, molecular biology, therapy, stem cell, mechanobiology, fibrosis, MIGS, gene therapy, clinical imaging