Topic Collection

Zhongjie Fu Boston Children’s Hospital, Harvard Medical School orcid.org/0000-0002-8182-2983   Michael Landowski University of Wisconsin-Madison orcid.org/0000-0003-0151-0689

Chuck T. Chen University of Toronto orcid.org/0000-0002-1099-4198   Qian Li Beijing Tongren Eye Center orcid.org/0000-0003-0613-9591

Dyslipidaemia is associated with many retinal metabolic diseases during development and aging. However, the role of lipids in retinal health is not well known. Dietary lipid invention exerts protection against neuronal and vascular retinal disorders (e.g., age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, as well as inherited retinal disorders etc) in patients across all age groups. However, the results of clinical trials are inconsistent, and the reasons are to be understood. Moreover, better understanding of the contribution of circulating versus retinal lipids to retinopathies, as well as the types of lipids involved is needed to facilitate the development and application of lipid-targeting drugs. Recent investigations have also shown lipids as mitochondrial substrates to support photoreceptor health, but there are still very limited studies in the field. In this Topic Collection, we focus on retinal lipid biology including lipid alterations and dyslipidaemia-associated metabolic changes (glucose, amino acid) in retinal diseases, targeting metabolism for disease prevention and treatment. Submissions on the following topics are welcome:

• Lipid role in retina and RPE
• Lipidomics, proteomics, transcriptomics, and metabolomics of dyslipidaemia-associated retinopathies
•  Lipid-lowering drugs for ocular diseases
•  Dietary lipid intervention for ocular diseases
• Clinical evaluation of lipemia retinalis and other lipid/metabolism associated retinal diseases

   

Both clinical and experimental studies are welcomed. Original Research articles and reviews will be preferred. Please see the instructions for authors for submission requirements for each article type. To submit your article, please follow these instructions and select ‘Lipids in Retinal Health and Disease’ as the Topic Collection. All submitted articles will be subject to the journal's normal peer review process. The Editor in Chief is responsible for the content of this Topic Collection. Guest Editors will manage peer review, invite reviewers and make a recommendation, but the final decision on all manuscripts will be made by the Editor-in-Chief. Articles accepted for publication will be published upon acceptance. Visit our author hub for more information regarding the publication process for topic collections. Authors submitting to this Topic Collection are entitled to a 25% discount on the Article Processing Charge. Discount is available upon request to info.bmjophth@bmj.com. For any inquiries regarding this topic collection, please contact topic.collections@bmj.com. Key words: Lipid, photoreceptor, retina, retinal pigment epithelium, fatty acids, aging, metabolism, dyslipidaemia, retinopathy

Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parameters (15 May 2024) Junhui Shen, Guangming Qin, Lei Feng