Fast signals and slow marks: the dynamics of histone modifications

TK Barth, A Imhof - Trends in biochemical sciences, 2010 - cell.com
Most multi-cellular organisms adopt a specific gene expression pattern during cellular
differentiation. Once established, this pattern is frequently maintained over several cell …

Two distinct modes for propagation of histone PTMs across the cell cycle

C Alabert, TK Barth, N Reverón-Gómez… - Genes & …, 2015 - genesdev.cshlp.org
Epigenetic states defined by chromatin can be maintained through mitotic cell division.
However, it remains unknown how histone-based information is transmitted. Here we …

[HTML][HTML] A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases

AM Bernhardt, S Tiedt, D Teupser, M Dichgans… - …, 2023 - thelancet.com
A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing
has been occurring over the past years in neurology. High-throughput methods, such as …

[PDF][PDF] Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX

N Lacoste, A Woolfe, H Tachiwana, AV Garea, T Barth… - Molecular cell, 2014 - cell.com
Centromeres are essential for ensuring proper chromosome segregation in eukaryotes.
Their definition relies on the presence of a centromere-specific H3 histone variant CenH3 …

[PDF][PDF] Redundant mechanisms to form silent chromatin at pericentromeric regions rely on BEND3 and DNA methylation

N Saksouk, TK Barth, C Ziegler-Birling, N Olova… - Molecular cell, 2014 - cell.com
Constitutive heterochromatin is typically defined by high levels of DNA methylation and H3
lysine 9 trimethylation (H3K9Me3), whereas facultative heterochromatin displays DNA …

SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres

M Gauchier, S Kan, A Barral, S Sauzet, E Agirre… - Science …, 2019 - science.org
Alternative lengthening of telomeres, or ALT, is a recombination-based process that
maintains telomeres to render some cancer cells immortal. The prevailing view is that ALT is …

Establishment of histone modifications after chromatin assembly

AND Scharf, TK Barth, A Imhof - Nucleic acids research, 2009 - academic.oup.com
Every cell has to duplicate its entire genome during S-phase of the cell cycle. After
replication, the newly synthesized DNA is rapidly assembled into chromatin. The newly …

[HTML][HTML] Decoding chromatin states by proteomic profiling of nucleosome readers

S Lukauskas, A Tvardovskiy, NV Nguyen, M Stadler… - Nature, 2024 - nature.com
DNA and histone modifications combine into characteristic patterns that demarcate
functional regions of the genome,. While many 'readers' of individual modifications have …

[HTML][HTML] Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1

S Sahar, S Masubuchi, K Eckel-Mahan… - Journal of Biological …, 2014 - ASBMB
The circadian clock regulates a wide range of physiological and metabolic processes, and
its disruption leads to metabolic disorders such as diabetes and obesity. Accumulating …

[HTML][HTML] On the impact of different approaches to classify age-related macular degeneration: Results from the German AugUR study

C Brandl, ME Zimmermann, F Günther, T Barth… - Scientific reports, 2018 - nature.com
While age-related macular degeneration (AMD) poses an important personal and public
health burden, comparing epidemiological studies on AMD is hampered by differing …