Fast signals and slow marks: the dynamics of histone modifications
TK Barth, A Imhof - Trends in biochemical sciences, 2010 - cell.com
Most multi-cellular organisms adopt a specific gene expression pattern during cellular
differentiation. Once established, this pattern is frequently maintained over several cell …
differentiation. Once established, this pattern is frequently maintained over several cell …
Two distinct modes for propagation of histone PTMs across the cell cycle
C Alabert, TK Barth, N Reverón-Gómez… - Genes & …, 2015 - genesdev.cshlp.org
Epigenetic states defined by chromatin can be maintained through mitotic cell division.
However, it remains unknown how histone-based information is transmitted. Here we …
However, it remains unknown how histone-based information is transmitted. Here we …
[HTML][HTML] A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases
AM Bernhardt, S Tiedt, D Teupser, M Dichgans… - …, 2023 - thelancet.com
A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing
has been occurring over the past years in neurology. High-throughput methods, such as …
has been occurring over the past years in neurology. High-throughput methods, such as …
[PDF][PDF] Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX
N Lacoste, A Woolfe, H Tachiwana, AV Garea, T Barth… - Molecular cell, 2014 - cell.com
Centromeres are essential for ensuring proper chromosome segregation in eukaryotes.
Their definition relies on the presence of a centromere-specific H3 histone variant CenH3 …
Their definition relies on the presence of a centromere-specific H3 histone variant CenH3 …
[PDF][PDF] Redundant mechanisms to form silent chromatin at pericentromeric regions rely on BEND3 and DNA methylation
N Saksouk, TK Barth, C Ziegler-Birling, N Olova… - Molecular cell, 2014 - cell.com
Constitutive heterochromatin is typically defined by high levels of DNA methylation and H3
lysine 9 trimethylation (H3K9Me3), whereas facultative heterochromatin displays DNA …
lysine 9 trimethylation (H3K9Me3), whereas facultative heterochromatin displays DNA …
SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres
Alternative lengthening of telomeres, or ALT, is a recombination-based process that
maintains telomeres to render some cancer cells immortal. The prevailing view is that ALT is …
maintains telomeres to render some cancer cells immortal. The prevailing view is that ALT is …
Establishment of histone modifications after chromatin assembly
AND Scharf, TK Barth, A Imhof - Nucleic acids research, 2009 - academic.oup.com
Every cell has to duplicate its entire genome during S-phase of the cell cycle. After
replication, the newly synthesized DNA is rapidly assembled into chromatin. The newly …
replication, the newly synthesized DNA is rapidly assembled into chromatin. The newly …
[HTML][HTML] Decoding chromatin states by proteomic profiling of nucleosome readers
DNA and histone modifications combine into characteristic patterns that demarcate
functional regions of the genome,. While many 'readers' of individual modifications have …
functional regions of the genome,. While many 'readers' of individual modifications have …
[HTML][HTML] Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1
S Sahar, S Masubuchi, K Eckel-Mahan… - Journal of Biological …, 2014 - ASBMB
The circadian clock regulates a wide range of physiological and metabolic processes, and
its disruption leads to metabolic disorders such as diabetes and obesity. Accumulating …
its disruption leads to metabolic disorders such as diabetes and obesity. Accumulating …
[HTML][HTML] On the impact of different approaches to classify age-related macular degeneration: Results from the German AugUR study
While age-related macular degeneration (AMD) poses an important personal and public
health burden, comparing epidemiological studies on AMD is hampered by differing …
health burden, comparing epidemiological studies on AMD is hampered by differing …