The article discusses a study which investigates the impact of glycemic exposure on the
brain function of youth with type 1 diabetes mellitus (T1DM). Mechanisms of how glycemic …

Background Glucocorticoids (GCs) can regulate hippocampal metabolism, physiologic
functions, and memory. Despite evidence of memory decreases during pharmacological GC …

N-methyl-D-aspartate (NMDA) glutamate receptor antagonists are reported to induce
schizophrenia-like symptoms in humans, including cognitive impairments. Shortcomings of …

Mapping of human brain function has revolutionized systems neuroscience. However,
traditional functional neuroimaging by positron emission tomography or functional magnetic …

Objective: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is
strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal …

Positron emission tomography (PET) measurements of cerebral glucose use were made in
18 patients with generalized anxiety disorder (GAD) during a passive viewing task off …

Objective: Despite the general consensus that youth with type 1 diabetes mellitus (T1DM)
can experience modest cognitive impairment, debate continues over the role of severe …

Sleep deprivation has been shown to have a rapid, nonpharmacologic antidepressant effect
in studies involving over 1,500 patients (1–3). In normal subjects sleep deprivation is …

This study is the first report on the effects of total sleep deprivation (about 32 h) on regional
cerebral glucose metabolism during wakefulness in man, using positron emission …

OBJECTIVE—Despite interest in the effects of type 1 diabetes on the developing brain,
structural brain volumes in youth with this disease have not previously been examined. This …