Silk fibroin in ocular tissue reconstruction

DG Harkin, KA George, PW Madden, IR Schwab… - Biomaterials, 2011 - Elsevier
The silk structural protein fibroin displays potential for use in tissue engineering. We present
here our opinion of its value as a biomaterial for reconstructing tissues of clinical …

Designing scaffolds for corneal regeneration

M Ahearne, J Fernández‐Pérez… - Advanced Functional …, 2020 - Wiley Online Library
Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

Human corneal endothelial cell growth on a silk fibroin membrane

PW Madden, JNX Lai, KA George, T Giovenco… - Biomaterials, 2011 - Elsevier
Tissue engineering of the cornea could overcome shortages of donor corneas for
transplantation and improve quality. Our aim was to grow an endothelial layer on a …

Silk fibroin safety in the eye: a review that highlights a concern

PW Madden, I Klyubin, MJ Ahearne - BMJ Open Ophthalmology, 2020 - bmjophth.bmj.com
The biomedical use of silk as a suture dates back to antiquity. Fibroin is the structural
element that determines the strength of silk and here we consider the safety of fibroin in its …

Deformation velocity imaging using optical coherence tomography and its applications to the cornea

S Lawman, PW Madden, V Romano, Y Dong… - Biomedical optics …, 2017 - opg.optica.org
Optical coherence tomography (OCT) can monitor human donor corneas non-invasively
during the de-swelling process following storage for corneal transplantation, but currently …

Engineering a corneal stromal equivalent using a novel multilayered fabrication assembly technique

J Fernández-Pérez, PW Madden… - Tissue Engineering Part …, 2020 - liebertpub.com
To overcome the serious shortage of donor corneas for transplantation, alternatives based
on tissue engineering need to be developed. Decellularized corneas are one potential …

Effect of the sterilization method on the properties of Bombyx mori silk fibroin films

KA George, AMA Shadforth, TV Chirila… - Materials Science and …, 2013 - Elsevier
We have compared the effects of different sterilization techniques on the properties of
Bombyx mori silk fibroin thin films with the view to subsequent use for corneal tissue …

[HTML][HTML] The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model

J Fernández-Pérez, PW Madden, RT Brady… - Plos one, 2021 - journals.plos.org
Decellularized porcine corneal scaffolds are a potential alternative to human cornea for
keratoplasty. Although clinical trials have reported promising results, there can be corneal …

The effect of polyvinylpyrrolidone and the cooling rate during corneal cryopreservation

PW Madden, MJ Taylor, CJ Hunt, DE Pegg - Cryobiology, 1993 - Elsevier
The effect upon endothelial cell survival of (a) PVP and (b) the cooling rate was investigated
during the cryopreservation of rabbit corneas with 3 mol/liter dimethyl suffoxide (Me 2 SO) …

Structural and kinetic characterization of myoglobins from eurythermal and stenothermal fish species

PW Madden, MJ Babcock, ME Vayda… - … and Physiology Part B …, 2004 - Elsevier
Teleost myoglobin (Mb) proteins from four fish species inhabiting different temperature
environments were used to investigate the relationship between protein function and …