Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

S Kajiyama, G Hasegawa, M Asano, H Hosoda… - Nutrition Research, 2008 - Elsevier
Oxidative stress is recognized widely as being associated with various disorders including
diabetes, hypertension, and atherosclerosis. It is well established that hydrogen has a …

Effect of eating vegetables before carbohydrates on glucose excursions in patients with type 2 diabetes

S Imai, M Fukui, S Kajiyama - Journal of clinical biochemistry and …, 2014 - jstage.jst.go.jp
抄録 The aim of this review was to evaluate whether eating vegetables before carbohydrates
could reduce the postprandial glucose, insulin, and improve long-term glycemic control in …

Diet, exercise, and pharmacotherapy for sarcopenia in people with diabetes

Y Hashimoto, F Takahashi, T Okamura, M Hamaguchi… - Metabolism, 2023 - Elsevier
Diabetes prevalence is increasing rapidly in older people, and sarcopenia is prevalent as a
novel complication, particularly in patients with type 2 diabetes mellitus (T2DM). Therefore …

Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease

H Park, T Shima, K Yamaguchi, H Mitsuyoshi… - Journal of …, 2011 - Springer
Background Hyperlipidemia, insulin resistance, and oxidative stress can heavily contribute
to the initiation and progression of nonalcoholic fatty liver disease (NAFLD). Currently, there …

Ectopic fat obesity presents the greatest risk for incident type 2 diabetes: a population-based longitudinal study

T Okamura, Y Hashimoto, M Hamaguchi… - International journal of …, 2019 - nature.com
Objectives Obesity is a risk factor for type 2 diabetes mellitus. Among obesity, visceral fat
obesity, and ectopic fat obesity, it has been unclear which has the greatest effect on incident …

Serum uric acid is associated with microalbuminuria and subclinical atherosclerosis in men with type 2 diabetes mellitus

M Fukui, M Tanaka, E Shiraishi, I Harusato, H Hosoda… - Metabolism, 2008 - Elsevier
Hyperuricemia has been reported to be associated with increased risk of renal insufficiency
as well as cardiovascular events. The aim of this study was to evaluate the relationships …

Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: relationship to glucose metabolism and biomarkers of insulin resistance

A Fujinami, K Ohta, H Obayashi, M Fukui… - Clinical …, 2008 - Elsevier
OBJECTIVES: The aims of this study were to measure serum levels of brain-derived
neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to …

[HTML][HTML] Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women

M Hamaguchi, T Kojima, A Ohbora… - World journal of …, 2012 - ncbi.nlm.nih.gov
AIM: To clarify the relationship between age, menopause, and nonalcoholic fatty liver
disease (NAFLD) in women. METHODS: We conducted a follow-up study on nonalcoholic …

[HTML][HTML] Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion

Y Minami, A Hoshino, Y Higuchi, M Hamaguchi… - Nature …, 2023 - nature.com
Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid
accumulation and subsequent inflammatory and profibrotic response. Therapeutic efforts at …

Metabolically healthy obesity and risk of incident CKD

Y Hashimoto, M Tanaka, H Okada… - Clinical journal of the …, 2015 - journals.lww.com
Results The crude incidence proportions of CKD were 2.6%(56 of 2122 participants) in
participants with the metabolically healthy nonobesity phenotype, 2.6%(8 of 302) in those …