Keratoconus, a non-inflammatory thinning of the cornea, is a leading indication for corneal
transplantation. For its causation, we propose a “Cascade Hypothesis” stating that …

This study localized malondialdehyde (MDA, a toxic byproduct of lipid peroxidation),
nitrotyrosine [NT, a cytotoxic byproduct of nitric oxide (NO)], and nitric oxide synthase …

Purpose: To review the pathological mechanisms and treatments for pseudophakic corneal
edema (PCE), one of the most common indications for penetrating keratoplasty. Methods …

MOTS-c, a 16 amino acid mitochondrial derived peptide, is encoded from the 12S rRNA
region of the mitochondrial genome. Under stress conditions, MOTS-c translocates to the …

purpose. The purpose of this study was to evaluate the ability of second-harmonic imaging
to identify differences in corneal stromal collagen organization between normal human and …

purpose. The mRNA levels of antioxidant enzymes, matrix metalloproteinases, cathepsin
V/L2, and tissue inhibitor of matrix metalloproteinases (TIMPs) were determined in …

purpose. Adult human corneal epithelial basement membrane (EBM) and Descemet's
membrane (DM) components exhibit heterogeneous distribution. The purpose of the study …

Geographic atrophy is a blinding form of age-related macular degeneration characterized by
retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency …

The geographic origins of populations can be identified by their maternally inherited
mitochondrial DNA (mtDNA) haplogroups. This study compared human cybrids (cytoplasmic …

purpose. To determine whether keratoconus (KC) corneal fibroblast cultures have increased
reactive oxygen species (ROS) production and are more susceptible to stress-related …