Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
K Kaarniranta, D Sinha, J Blasiak, A Kauppinen… - Autophagy, 2013 - Taylor & Francis
Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye
disease that usually does not lead to complete blindness, but can result in severe loss of …
disease that usually does not lead to complete blindness, but can result in severe loss of …
Resveratrol in cardiovascular health and disease
G Petrovski, N Gurusamy… - Annals of the New York …, 2011 - Wiley Online Library
Resveratrol, initially used for cancer therapy, has shown beneficial effects against most
degenerative and cardiovascular diseases from atherosclerosis, hypertension …
degenerative and cardiovascular diseases from atherosclerosis, hypertension …
[HTML][HTML] Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration
J Blasiak, G Petrovski, Z Veréb, A Facskó… - BioMed research …, 2014 - hindawi.com
Age-related macular degeneration (AMD) is the leading cause of severe and irreversible
loss of vision in the elderly in developed countries. AMD is a complex chronic …
loss of vision in the elderly in developed countries. AMD is a complex chronic …
Molecular mechanisms of retinal pigment epithelium damage and development of age‐related macular degeneration
K Kinnunen, G Petrovski, MC Moe, A Berta… - Acta …, 2012 - Wiley Online Library
Age‐related macular degeneration (AMD) is attributed to a complex interaction of genetic
and environmental factors. It is characterized by degeneration involving the retinal …
and environmental factors. It is characterized by degeneration involving the retinal …
Cell death and autophagy: cytokines, drugs, and nutritional factors
W Bursch, A Karwan, M Mayer, J Dornetshuber… - Toxicology, 2008 - Elsevier
Cells may use multiple pathways to commit suicide. In certain contexts, dying cells generate
large amounts of autophagic vacuoles and clear large proportions of their cytoplasm, before …
large amounts of autophagic vacuoles and clear large proportions of their cytoplasm, before …
[HTML][HTML] Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells
J Viiri, M Amadio, N Marchesi, JMT Hyttinen, N Kivinen… - PloS one, 2013 - journals.plos.org
Age-related macular degeneration (AMD) is the most common reason of visual impairment
in the elderly in the Western countries. The degeneration of retinal pigment epithelial cells …
in the elderly in the Western countries. The degeneration of retinal pigment epithelial cells …
[HTML][HTML] ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages
Pathogen-activated and damage-associated molecular patterns activate the inflammasome
in macrophages. We report that mouse macrophages release IL-1β while co-incubated with …
in macrophages. We report that mouse macrophages release IL-1β while co-incubated with …
Simplified meal announcement versus precise carbohydrate counting in adolescents with type 1 diabetes using the MiniMed 780G advanced hybrid closed loop …
G Petrovski, J Campbell, M Pasha, E Day… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE We aimed to compare glucose control in adolescents with type 1 diabetes
(T1D) using the MiniMed 780G system who used simplified meal announcement with those …
(T1D) using the MiniMed 780G system who used simplified meal announcement with those …
[HTML][HTML] Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
S Felszeghy, J Viiri, JJ Paterno, JMT Hyttinen… - Redox biology, 2019 - Elsevier
Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading
cause of irreversible and severe vision loss in the developed countries. It has been …
cause of irreversible and severe vision loss in the developed countries. It has been …
Cardioprotection by endoplasmic reticulum stress–induced autophagy
This study tested the hypothesis that the induction of autophagy by producing therapeutic
amounts of endoplasmic reticulum (ER) stress in the heart before an ischemic insult would …
amounts of endoplasmic reticulum (ER) stress in the heart before an ischemic insult would …