User profiles for "author:Fraser Brown"

Fraser Brown

- Verified email at tonnard.co.uk - Cited by 1665

Fraser Brown

- Verified email at andrew.cmu.edu - Cited by 561

The Beaker phenomenon and the genomic transformation of northwest Europe

I Olalde, S Brace, ME Allentoft, I Armit, K Kristiansen… - Nature, 2018 - nature.com
From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and
central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled …

Phosphatidylinositol 4, 5-bisphosphate and Arf6-regulated membrane traffic

FD Brown, AL Rozelle, HL Yin, T Balla… - The Journal of cell …, 2001 - rupress.org
ADP-ribosylation factor (Arf) 6 regulates the movement of membrane between the plasma
membrane (PM) and a nonclathrin-derived endosomal compartment and activates …

Large-scale migration into Britain during the Middle to Late Bronze Age

N Patterson, M Isakov, T Booth, L Büster, CE Fischer… - Nature, 2022 - nature.com
Present-day people from England and Wales have more ancestry derived from early
European farmers (EEF) than did people of the Early Bronze Age 1. To understand this, here …

[HTML][HTML] Systematic review of prediction models in relapsing remitting multiple sclerosis

FS Brown, SA Glasmacher, PKA Kearns… - PLoS …, 2020 - journals.plos.org
The natural history of relapsing remitting multiple sclerosis (RRMS) is variable and
prediction of individual prognosis challenging. The inability to reliably predict prognosis at …

Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains

LA Cohen, A Honda, P Varnai, FD Brown… - Molecular biology of …, 2007 - Am Soc Cell Biol
ARNO is a soluble guanine nucleotide exchange factor (GEF) for the Arf family of GTPases.
Although in biochemical assays ARNO prefers Arf1 over Arf6 as a substrate, its localization …

ACAPs are arf6 GTPase-activating proteins that function in the cell periphery

TR Jackson, FD Brown, Z Nie, K Miura… - The Journal of cell …, 2000 - rupress.org
The GTP-binding protein ADP-ribosylation factor 6 (Arf6) regulates endosomal membrane
trafficking and the actin cytoskeleton in the cell periphery. GTPase-activating proteins …

[PDF][PDF] Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation

FD Brown, N Thompson, KM Saqib, JM Clark… - Current Biology, 1998 - cell.com
Phospholipase D (PLD) activity has been implicated in the regulation of membrane
trafficking [1, 2], superoxide generation and cytoskeletal remodelling [3, 4]. Several PLD …

Falls in progressive supranuclear palsy

FS Brown, JB Rowe, L Passamonti… - Movement disorders …, 2020 - Wiley Online Library
Background Despite falls being an almost universal clinical feature and central to the
presentation and diagnostic criteria of progressive supranuclear palsy, our understanding of …

[BOOK][B] Rethinking children's play

F Brown, M Patte - 2012 - books.google.com
Rethinking Children's Play examines attitudes towards, and experiences of, children's play.
Fraser Brown and Michael Patte draw on a wide range of thought, research and practice …

Fact: a DSL for timing-sensitive computation

S Cauligi, G Soeller, B Johannesmeyer… - Proceedings of the 40th …, 2019 - dl.acm.org
Real-world cryptographic code is often written in a subset of C intended to execute in
constant-time, thereby avoiding timing side channel vulnerabilities. This C subset eschews …