The pharmacology and clinical use of methotrexate

N Engl J Med. 1983 Nov 3;309(18):1094-104. doi: 10.1056/NEJM198311033091805.
No abstract available

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Biological Transport / drug effects
  • Central Nervous System / metabolism
  • Drug Resistance
  • Folic Acid / metabolism
  • Folic Acid Antagonists
  • Gene Amplification
  • Head and Neck Neoplasms / drug therapy
  • Humans
  • Kinetics
  • Leucovorin / administration & dosage
  • Leukemia, Lymphoid / drug therapy
  • Lung Neoplasms / drug therapy
  • Methotrexate / metabolism
  • Methotrexate / pharmacology
  • Methotrexate / therapeutic use*
  • Neoplasms / drug therapy
  • Neoplasms / enzymology
  • Osteoma, Osteoid / drug therapy
  • Thymidylate Synthase / metabolism
  • Tissue Distribution

Substances

  • Folic Acid Antagonists
  • Folic Acid
  • Thymidylate Synthase
  • Leucovorin
  • Methotrexate