Abstract
Retinopathy of prematurity occurs because the retina of a preterm infant at birth is incompletely vascularized, and if the postnatal environment does not match the in utero environment that supported retinal development, the vessels and neural retina will not grow normally. Risk factors determined from many clinical studies and animal studies fall into 2 categories: prenatal factors and postnatal factors.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Erythropoietin / metabolism
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Humans
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Infant
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Infant, Newborn
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Infant, Premature / metabolism*
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Insulin-Like Growth Factor I / metabolism
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Oxygen / therapeutic use*
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Retina / pathology*
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Retinopathy of Prematurity / etiology*
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Retinopathy of Prematurity / metabolism
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Retinopathy of Prematurity / therapy
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Vascular Endothelial Growth Factor A
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Erythropoietin
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Insulin-Like Growth Factor I
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Oxygen