Abstract
During the past decade, array CGH has been applied to study copy number alterations in the genome in human leukemia in relation to prediction of prognosis or responsiveness to therapy. In the first segment of this review, we will focus on the identification of acquired mutations by array CGH, followed by studies on the pathogenesis of leukemia associated with germline genetic variants, phenotypic presentation and response to treatment. In the last section, we will discuss constitutional genomic aberrations causally related to myeloid leukemogenesis.
Copyright © 2011 S. Karger AG, Basel.
MeSH terms
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Chromosome Aberrations
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Comparative Genomic Hybridization*
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Genetic Predisposition to Disease
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Leukemia, Myeloid, Acute / diagnosis
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Leukemia, Myeloid, Acute / genetics*
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Multiple Myeloma / diagnosis
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Multiple Myeloma / genetics
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Myelodysplastic Syndromes / diagnosis
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Myelodysplastic Syndromes / genetics
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Oligonucleotide Array Sequence Analysis*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Syndrome
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Thrombocytopenia / congenital