Bilateral response following unilateral intravitreal bevacizumab injection in a child with uveitic cystoid macular edema

J AAPOS. 2009 Aug;13(4):400-2. doi: 10.1016/j.jaapos.2009.03.006. Epub 2009 May 30.

Abstract

Untreated cystoid macular edema (CME) is a major cause for visual loss in intermediate and posterior forms of uveitis. Conventional treatments for inflammatory CME include steroids, nonsteroidal antiinflammatory agents, and carbonic anhydrase inhibitors; however, not all patients respond, even after quieting of the uveitis. Intravitreal injection of bevacizumab, a monoclonal antibody to vascular endothelial growth factor, has recently been suggested as a short-term treatment for inflammatory CME in adults. Because unilaterally injected bevacizumab can reach the contralateral eye via the systemic circulation there may be a contralateral clinical effect; however, the few reports that evaluate this in adults are conflicting. The purpose of this report is to document bilateral reduction of uveitic CME following unilateral intravitreal bevacizumab injection in an 8-year-old girl.

Publication types

  • Case Reports

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage*
  • Antibodies, Monoclonal / administration & dosage*
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Child
  • Female
  • Functional Laterality
  • Humans
  • Injections
  • Intraocular Pressure
  • Macular Edema / diagnosis
  • Macular Edema / drug therapy*
  • Tomography, Optical Coherence
  • Uveitis, Intermediate / diagnosis
  • Uveitis, Intermediate / drug therapy*
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • Visual Acuity
  • Vitreous Body

Substances

  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Vascular Endothelial Growth Factor A
  • Bevacizumab