BRIEF REPORT
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

https://doi.org/10.1111/jth.14768Get rights and content
Under an Elsevier user license
open archive

Abstract

Background

In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.

Objectives

To describe the coagulation feature of patients with NCP.

Methods

Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed.

Results

The overall mortality was 11.5%, the non‐survivors revealed significantly higher D‐dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non‐survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.

Conclusions

The present study shows that abnormal coagulation results, especially markedly elevated D‐dimer and FDP are common in deaths with NCP.

Keywords

coagulation parameter
D‐dimer
disseminated intravascular coagulation
fibrin degradation product
novel coronavirus pneumonia

Cited by (0)

Manuscript handled by: David Lillicrap

Final decision: David Lillicrap, 18 February 2020