Cell Stem Cell
Volume 22, Issue 6, 1 June 2018, Pages 834-849
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Review
Regenerating Eye Tissues to Preserve and Restore Vision

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Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age-related macular degeneration. A variety of transplantable products, delivered as cell suspensions or as preformed 3D structures combining cells and natural or artificial substrates, are in the pipeline. Here we review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including bioengineering approaches that advance cell product manufacturing. While recognizing the challenges, we look forward to a deep portfolio of sight-restoring, stem cell-based medicine.

Keywords

eye
ocular
regenerative medicine
ophthalmology
retinal pigment epithelium
retina
photoreceptors
stem cells
limbal
cornea
trabecular meshwork
retinal ganglion cells
lens
optic nerve

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