Original articleSpectral-Domain Optical Coherence Tomography Angiography of Choroidal Neovascularization
Section snippets
Methods
This study was approved by the institutional review board of Tufts Medical Center. Informed consent was obtained from patients in accordance with the Tufts Medical Center Institutional Review Board before examination. The research adhered to the tenets of the Declaration of Helsinki and complied with the Health Insurance Portability and Accountability Act of 1996. In this retrospective review, patients who underwent OCTA using the prototype AngioVue OCTA system on the commercially available
Results
Choroidal neovascularization was visualized on OCTA in 48 eyes of 43 subjects. Six of these eyes of 6 patients also were reviewed in the overlapping cohort in which same-day FA and OCTA were evaluated for sensitivity and specificity calculations. Including these 6 eyes, the cohort contained 30 eyes of 24 subjects. Therefore, in total, this study included 72 eyes from 61 subjects. All eyes evaluated in this study demonstrated agreement between 3×3-mm and 6×6-mm OCTA images.
Forty-eight eyes of 43
Discussion
Jia et al4 reported 5 cases of CNV and compared them with normal eyes using OCTA from a prototype SS OCT and hinted at the potential future usefulness of OCTA in quantifying CNV. Their prototype system operated at 100 000 A-scans per second to acquire 200×200 A-scans in 3.5 seconds. Orthogonal registration and merging of 4 scans then were used to create 3×3-mm OCTA images. The series presented in this manuscript is a larger qualitative and quantitative study that investigated OCTA imaging using
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Financial Disclosure(s): The author(s) have made the following disclosure(s): J.S.D.: Consultant and financial support − Carl Zeiss Meditec, Inc. (Dublin, CA) and OptoVue, Inc. (Fremont, CA).
Supported in part by an unrestricted grant form Research to Prevent Blindness, Inc., New York, New York, to the New England Eye Center/Department of Ophthalmology, Tufts University School of Medicine; and by the Massachusetts Lions Eye Research Fund, Inc (New Bedford, MA).
Author Contributions:
Conception and design: de Carlo, Bonini Filho, Ferrara, Baumal, Witkin, Duker, Waheed
Analysis and interpretation: de Carlo, Bonini Filho, Chin, Adhi, Waheed
Data collection: de Carlo, Bonini Filho, Chin, Baumal, Witkin, Reichel, Duker, Waheed
Obtained funding: Not applicable
Overall responsibility: de Carlo, Bonini Filho, Chin, Adhi, Ferrara, Baumal, Witkin, Reichel, Duker, Waheed