Original articleClinical Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa
Section snippets
Patients
This retrospective study included 371 consecutive patients (167 male and 204 female) diagnosed with typical RP, as well as 165 control patients (89 male and 76 female) without active inflammation-associated diseases, such as uveitis or proliferative diabetic retinopathy. Eyes with a history of intraocular operation were excluded. The characteristics of these patients are shown in Table 1. All patients in this study were seen at Kyushu University Hospital (Fukuoka, Japan). Written, informed
Density of Inflammatory Cells in the Anterior Vitreous by Slit-lamp Biomicroscopy
We assessed the inflammatory cell density in the anterior vitreous cavity of 371 RP patients and 165 control patients by slit-lamp biomicroscopy. The distribution of density of inflammatory cells according to age is shown in Figure 1. Occasional or more cells in the vitreous cavity were identified in 61.5% (313 eyes) of 509 eyes with RP; 1+ or more cells were observed in 37.3% (190 eyes). There was no patient with 3+ or more cells. Notably, stronger inflammatory reaction with 2+ cells were more
Discussion
Retinitis pigmentosa is a heterogeneous group of inherited retinal diseases resulting in adult blindness. Although various genetic mutations have been identified in patients with RP, the mechanisms by which these mutations lead to photoreceptor apoptosis remain largely unknown. Previous studies have reported the presence of an inflammatory reaction in the eyes of patients with RP.7, 8 However, the relationship between inflammation and visual function and the underlying molecular changes has not
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Manuscript no. 2011-1790.
Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.