Original articleDescemet's Stripping Endothelial Keratoplasty: Long-term Graft Survival and Risk Factors for Failure in Eyes with Preexisting Glaucoma
Section snippets
Materials and Methods
In this institutional review board–approved study, 835 DSEK cases performed between December 2003 and August 2007 at Price Vision Group (Indianapolis, IN) were retrospectively reviewed. All patients read and signed an informed consent document for the transplant procedure, as well as an informed consent document allowing their medical information to be used for research purposes. The study was conducted in accordance with good clinical practices, the Declaration of Helsinki, and the Health
Results
On the basis of the inclusion and exclusion criteria, 453 eyes qualified for the study; 348 eyes were classified as a group without preexisting glaucoma (C), 65 eyes had medically managed glaucoma (G), and 46 eyes had surgically managed glaucoma (GS). Overall, the cases that qualified for the study did not differ significantly in key characteristics from cases that did not qualify because of lack of at least 1 year follow-up (P > 0.05). The mean follow-up duration was 4 years (range, 1–7 years).
Discussion
This study reports for the first time the long-term corneal graft survival and risk factors for graft survival in eyes with preexisting glaucoma in a large DSEK cohort. The 5-year graft survival was significantly lower in eyes with prior glaucoma surgery, especially so in eyes with preexisting GDD. In a multivariate model evaluating potential risk factors for graft survival, prior glaucoma surgery (P < 0.0001), and occurrence of a rejection episode (P = 0.0023) were significant risk factors for
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2022, American Journal of OphthalmologyCitation Excerpt :Race was not found to be a risk factor for graft rejection after DSAEK in the Cornea Preservation Time Study2; however, most study participants (90.2%) were White. Furthermore, many of these studies have small sample sizes that limit the ability to adjust for surgical indication and ocular comorbidities such as glaucoma, which are known to impact graft survival.16,17 The current IRIS Registry analysis adjusted for many factors known to affect graft survival after EK, including the EK indication, ocular comorbidities, and postoperative complications.
Corneal Edema and Keratoplasty: Risk Factors in Eyes With Previous Glaucoma Drainage Devices
2022, American Journal of OphthalmologyLong-term Outcomes of Descemet Stripping Endothelial Keratoplasty: Ten-Year Graft Survival and Endothelial Cell Loss
2022, American Journal of OphthalmologyChanges in the Visual Field Test after Descemet Stripping Automated Endothelial Keratoplasty in Advanced Glaucoma
2024, Journal of Clinical Medicine
Manuscript no. 2012-157.
Financial Disclosure(s): The author(s) have made the following disclosure(s): Marianne O. Price and Francis W. Price received a travel grant from Moria. Arundhati Anshu has no conflict of interest to disclose.