Original articleAnthropometric Measures and their Relation to Incident Primary Open-Angle Glaucoma
Section snippets
Description of the Cohort at Risk for Primary Open-Angle Glaucoma
The Nurses' Health Study (NHS) is an ongoing, population-based cohort of registered nurses. The NHS was established in 1976, when 121 700 American women were invited to complete a questionnaire regarding lifestyle, health behavior, and chronic diseases. The Health Professionals Follow-Up Study (HPFS) is an ongoing cohort created in 1986 when 51 529 male healthcare providers (dentists, veterinarians, pharmacists, optometrists, osteopaths, and podiatrists) completed a similar health survey. The
Results
During 1 610 334 person-years of follow-up, 980 incident POAG cases were identified. As expected, participants with higher BMI had higher rates of hypertension and DM (Table 1). They also were less likely to be physically active or to consume alcohol or smoke cigarettes. These potential confounders were accounted for in multivariate analyses.
Compared with the reference group of cumulatively averaged BMI in the 24- to 25-kg/m2 range (Table 2), there were no significant associations with very low
Discussion
This prospective study did not show associations between cumulatively averaged BMI and POAG overall. Interestingly, significant inverse relations were found between higher BMI and POAG with IOP of 21 mmHg or less among women, but not among men. Height was not associated with risk of POAG. The trends reported here are consistent with prior cross-sectional data,25, 30 although the gender-specific nature of the trend has not been reported previously. The significant inverse association observed
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2023, American Journal of OphthalmologyAssociation Between Body Mass Index and Primary Open Angle Glaucoma in Three Cohorts
2023, American Journal of OphthalmologyCitation Excerpt :This study illustrated novel associations between BMI and longitudinal glaucoma outcomes. Multiple cross-sectional studies have proposed an inverse correlation between BMI and risk of glaucoma diagnosis.2,4–6,16 Lin and associates correlated a low BMI with a 2-fold risk of glaucoma diagnosis in their analysis of 10,978 South Korean participants from the Korean National Health and Nutrition Examination Survey.16
Non-drug interventions in glaucoma: Putative roles for lifestyle, diet and nutritional supplements
2022, Survey of OphthalmologyOcular blood flow as a clinical observation: Value, limitations and data analysis
2020, Progress in Retinal and Eye ResearchCitation Excerpt :Multiple studies have investigated the relationship between OAG and body mass index (BMI) with conflicting results (Kim et al., 2014; Kyari et al., 2016; Lin et al., 2018; Pasquale et al., 2010; Springelkamp et al., 2017). Some studies showed an increased risk for OAG in subjects with lower BMI (Kyari et al., 2016; Lin et al., 2018; Pasquale et al., 2010; Springelkamp et al., 2017). However, a higher BMI has also been shown to be a risk factor for progression to glaucoma (Kim et al., 2014).
Manuscript no. 2009-973.
Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.