Original articleCorrelation between Ocular Demodex Infestation and Serum Immunoreactivity to Bacillus Proteins in Patients with Facial Rosacea
Section snippets
Patients
This study followed the tenets of the Helsinki Declaration of Human Studies and has been approved by the ethics committee of the Ocular Surface Research and Education Foundation. A total of 59 patients who presented with a number of ocular surface diseases (Table 1; available online at http://aaojournal.org) were consecutively enrolled in the Ocular Surface Center (Miami, FL) from September 2008 to April 2009. For all patients, in addition to routine complete eye examinations, photographs were
Results
The 59 patients consisted of 34 men and 25 women with a mean age of 60.4±17.6 years (range, 17–93). Their age distribution was not different when they were subdivided into 2 groups according to the presence or absence of serum immunoreactivity, ocular Demodex infestation, facial rosacea, or aqueous tear-deficiency dry eye (P = 0.151, 0.805, 0.868, and 0.706, respectively; Table 2). When the Demodex counts were analyzed, we did not note any significant correlation in the age distribution
Discussion
Lacey et al23 first linked skin mite infestation and microbial infection to explain why cutaneous inflammation occurs in facial rosacea. Specifically, their experimental evidence supports the notion that cutaneous inflammation might be exacerbated by strong host immune responses to proteins produced by B oleronius living inside Demodex mites. Herein, our collaborative study further established the comorbidity between Demodex infestation and Bacillus infection in facial rosacea. This finding
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Successful management of chronic Blepharo-rosacea associated demodex by lid scrub with terpinen-4-ol
2021, American Journal of Ophthalmology Case ReportsCitation Excerpt :In addition, demodex complicates the clinical course and was found more prevalent in patients with chronic severe rosacea compared to rosacea without demodex involvement.3 These mites may link to the chronicity of disease by stimulating the inflammatory process which subsequently leads to tissue damage and aggravation of telangiectasias.1,4 Previously, it was reported eyelid scrubs with tea tree oil (TTO) are effective in reducing demodex counts and ocular surface inflammation.
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2024, Journal of Inflammation ResearchAnalysis of infection of fungi, bacteria and Demodex in eyelid margin of non-blepharitis and blepharitis
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Manuscript no. 2009-896.
NOR is the recipient of a Hume Scholarship.
Financial Disclosure(s): The authors have made the following disclosures: Scheffer C. G. Tseng has filed 2 patents for the use of tea tree oil and its ingredients for treating demodicosis.