Original articleHalf-Dose Verteporfin Photodynamic Therapy for Acute Central Serous Chorioretinopathy: One-Year Results of a Randomized Controlled Trial
Section snippets
Study Design and Patient Recruitment
This study was a prospective, double-masked, randomized placebo-controlled trial conducted in the Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong. Patients with acute symptomatic CSC of 3 months' duration or less were recruited from Hong Kong Eye Hospital and Prince of Wales Hospital from December 2004 through December 2005. Inclusion criteria included: (1) patients with best-corrected visual acuity (BCVA) of 20/200 or better; (2) presence of subretinal
Results
Sixty-three eyes in 63 patients with acute CSC were recruited, of which 42 eyes were randomized to safety-modified PDT with half-dose verteporfin and 21 eyes were randomized to placebo. Figure 1 shows the flow of the patients in the study. At 12 months, 5 patients (3 in the verteporfin group and 2 in the placebo group) were lost to follow-up, and the remaining 58 (92.1%) patients were included in the analysis. The mean age±standard deviation (SD) of the patients was 41.0±6.7 years (range, 25–58
Discussion
Although CSC generally is considered as a self-limiting and benign condition, some patients may experience significant visual impairment caused by recurrent attacks of CSC, persistent chronic neurosensory retinal detachment, or RPE atrophy.5, 6 Moreover, because many patients are of working age, visual symptoms may interfere with their activities considerably. The ideal treatment option for CSC would be one that can result in visual improvement, can shorten the duration of symptoms, and can
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A randomized non-inferiority trial of 577nm subthreshold micropulse laser versus half-dose photodynamic therapy for acute central serous chorioretinopathy
2024, Photodiagnosis and Photodynamic TherapyExamining the efficacy of verteporfin photo-dynamic therapy (PDT) at different dose & fluence levels
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2022, Progress in Retinal and Eye ResearchCitation Excerpt :Both clinical and histopathologic examinations have observed notable effects of verteporfin PDT on the choroidal vasculature and RPE. These effects include occlusion in choroidal vessels and necrosis of endothelial cells, particularly in the choriocapillaris at low energy levels (Chan et al., 2008; Kramer et al., 1996; Schmidt-Erfurth et al., 1994; Yannuzzi et al., 2012). Effective occlusion of normal choroidal vessels was achieved at 2 mg/kg using 2.3–7.5 J/cm2 or at 10 mg/kg using 0.46–0.75 J/cm2 with minimal injury to the overlying retina (Mori et al., 1999).
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2024, International Ophthalmology Clinics
Manuscript no. 2008-150.
Financial Disclosure(s): Dr Lai has served as a consultant to an advisory board of Novartis, Inc. All other authors have no financial interest to declare.