Original articleOptical Coherence Tomography Measurements and Analysis Methods in Optical Coherence Tomography Studies of Diabetic Macular Edema
Section snippets
Materials and Methods
The specific objectives of this report are (1) to identify the optimal OCT measurement for central macular thickening in DME; (2) to identify roles for paracentral and global macular OCT measurements and explore correlations between these measurements and their changes in DME and treatments for DME; and (3) to identify limitations and advantages in 3 methods of analysis of OCT measurement changes—namely, (a) absolute change in thickness, (b) relative change in thickness, and (c) relative change
Optical Coherence Tomography Outcomes for the Center of the Macula
Center point thickness and central subfield mean thickness are 2 measures of the central portion of the macula printed on the Zeiss OCT Retinal Map Analysis. For the 2 studies, the correlation between these 2 measures at baseline was 0.98, and 0.99, respectively.2, 3 The correlation coefficients for change in CPT and change in CSMT in the mETDRS versus MMG trial and the diurnal variation study at their primary follow-up end points were 0.98 and 0.87, respectively.
As a result of these high
Preferred Optical Coherence Tomography Measurement for the Central Macula
Published studies on OCT measurements in DME have reported CPT and CSMT, often under synonymous names (Table 1 [available at http://aaojournal.org]). Chan and Duker were the first to identify the basis for preferring CSMT as a measurement of the central macular thickness, and we agree with their published rationale. They noted that CSMT should have a higher reproducibility because it is based on more scans than CPT. A DRCR.net reproducibility study in DME has confirmed this prediction.16 The
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2021, Progress in Retinal and Eye ResearchCitation Excerpt :Cross-sectional scans are the other common OCTA representation. Cross-sectional scans are frequently used in structural OCT in order to detect pathology such as edema (through identification of either fluid pockets or abnormal thickening of the retina), detachments, or disorganization of retinal layers (Browning et al., 2008; Das et al., 2018; Prager et al., 2014; Sun et al., 2015). Fewer features are measured using cross-sectional OCTA due to the orientation of retinal vascular plexuses (Campbell et al., 2017).
Manuscript no. 2007-1111.
Supported through a cooperative agreement from the National Eye Institute, Bethesda, Maryland (nos. EY14231, EY14269, EY14229).
A current list of the Diabetic Retinopathy Clinical Research Network and DRCR.net investigator financial disclosures are available at http://www.drcr.net.