Original ArticleRelationship between Optical Coherence Tomography–Measured Central Retinal Thickness and Visual Acuity in Diabetic Macular Edema
Section snippets
Patients and Methods
This study analyzed data collected from a multicenter randomized clinical trial comparing modified Early Treatment of Diabetic Retinopathy (ETDRS) laser photocoagulation with a modified macular grid approach for the treatment of DME (protocol available at http://public.drcr.net; accession date, May 13, 2006). The study, funded by the National Eye Institute of the National Institutes of Health, U.S. Department of Health and Human Services, was conducted by the Diabetic Retinopathy Clinical
Results
The study included 210 participants, of whom 41 (20%) had 2 study eyes and 169 (80%) had 1 study eye, for a total of 251 eyes. Baseline characteristics of the participants and of the study eyes are provided in Table 1.
Discussion
Although it has long been appreciated that central macular thickening can be associated with a decrease in visual acuity and that treatments that reduce such retinal thickening can improve vision, quantitative evaluation of these relationships and the effect of laser photocoagulation are scarce. In this study, we documented a modest correlation between best-corrected visual acuity and OCT center point thickness before focal laser photocoagulation, as well as a modest correlation between change
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Manuscript no. 2006-373.
Supported by a cooperative agreement from the National Eye Institute, Bethesda, Maryland, and National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland (grant nos.: EY14231, EY14269, EY14229).