Original articleCrystalline Lens Optical Dysfunction through Aging
Section snippets
Population
In this cross-sectional observational study, 72 patients were examined. Subjects were recruited consecutively between January and May 2003 at VISSUM, Instituto Oftalmológico de Alicante, Spain. Only one eye from each subject was studied.
The male to female ratio was 26/46, and the age of the subjects ranged from 8 to 80 years (41±21 [mean ± standard deviation (SD)]). The spherical equivalent (SE) refraction ranged from −3.00 to +2.75 diopters (D) (0.40±1.25 [mean ± SD]).
The tenets of the
Results
Results were first analyzed for the entire population, then subjects were arbitrarily divided into 4 age groups: group 1 included subjects from 8 to 20 years old (n = 15); group 2, subjects from 21 to 40 (n = 20); group 3, subjects from 41 to 60 (n = 21); and group 4, subjects from 61 to 80 (n = 16).
Nucleus density is represented in Figure 4, Figure 5, Figure 6. Densities of embryonic, anterior fetal, and posterior fetal nuclei show a positive correlation with aging after the age of 40 (r =
Discussion
In the present study, we analyzed the densitometric changes that take place in the crystalline lens with aging and how these changes affect the optical quality of the eye. Densitometric changes were studied on the lens nucleus, which is the oldest anatomical region of the crystalline lens.
In our study, nucleus density showed a positive correlation with age, after 40 years, for embryonic, anterior fetal, and posterior fetal nuclei. When different age groups are analyzed, we can see that nucleus
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Manuscript no. 2004-201.
This study has been supported in part by a grant of the Spanish Ministry of Health, Instituto Carlos III, Red Temática de Investigación en Oftalmología, Subproyecto de Cirugía Refractiva y Calidad Visual, Madrid, Spain (grant no.: C03/13).
The authors have no proprietary interest in any of the materials or methods described herein.