Journal of American Association for Pediatric Ophthalmology and Strabismus
Apt LectureIris melanoma: Features and prognosis in 317 children and adults
Section snippets
Methods
This retrospective, nonrandomized clinical case series included all patients with a clinical diagnosis of iris melanoma managed at the Ocular Oncology Service at Wills Eye Institute between August 25, 1970 and May 1, 2011. Institutional review board approval was obtained for this study. The patients were divided into three age categories based on age at presentation: children (≤20 years), mid-adults (21-60 years), and older adults (>60 years). All patients were examined by one of the senior
Results
Of 317 eyes in 317 patients with iris melanoma, 24 (8%) were in young patients (≤20 years), 187 (59%) in mid-adults (21-60 years), and 106 (33%) in older adults (>60 years). A comparison of the features based on age (children, mid-adults, older adults) was made. The patient demographic data are listed in Table 1. Iris melanoma occurred in 98% of whites and 2% of nonwhites without statistical difference in race, sex, or laterality among age groups.
The clinical features of iris melanoma are
Discussion
According to the Surveillance, Epidemiology, and End Results database, the mean age-adjusted incidence of uveal melanoma in the United States is 5.1 cases per million population.2, 3, 7 The age-specific incidence of uveal melanoma reveals increasing incidence with age (males, females per million population) as follows: 0-4 years (0, 0), 10-14 years (0.2, 0), 20-24 years (0.4, 0.6), 30-34 years (1.7, 1.7), 40-44 years (3.9, 2.4), 50-54 years (10.5, 6.5), 60-64 years (14.9, 11.7), 70-74 years
References (22)
- et al.
Uveal melanoma: Trends in incidence, treatment, and survival
Ophthalmology
(2011) - et al.
Incidence of uveal melanoma in the United States:1973-1997
Ophthalmology
(2003) - et al.
Uveal melanoma in teenagers and children: A report of 40 cases
Ophthalmology
(1991) - et al.
Prognostic parameters in uveal melanoma: A review
Surv Ophthalmol
(1996) - et al.
Iris melanoma: Risk factors for metastasis in 169 consecutive patients
Ophthalmology
(2001) The melanoma controversy: A comparison of choroidal, cutaneous, and iris melanomas
Surv Ophthalmol
(1981)- et al.
Vascular tumors of the retina and optic disc
- et al.
Metastasis of uveal melanoma millimeter-by-millimeter in 8,033 consecutive eyes
Arch Ophthalmol
(2009) Uveal melanomas in children and adolescents
Int Ophthalmol Clin
(1962)- et al.
Melanomas of eye: Stability of rates
Am J Epidemiol
(1981)
Primary tumors of the iris
AMA Arch Ophthalmol
Cited by (0)
Financial support: Provided by a donation from Michael, Bruce, and Ellen Ratner, New York, New York (JAS, CLS) and the Eye Tumor Research Foundation, Philadelphia, Pennsylvania (CLS, JAS). Statistical analysis provided by Rishita Nutheti, PhD, Hyderabad, India.