Original articleSpectral-domain Optical Coherence Tomography Retinal and Choroidal Thickness Metric Repeatability in Age-related Macular Degeneration
Section snippets
Methods
This study analysis formed part of the Distance of Choroid Study (DOCS). This was a prospective cross-sectional study assessing the repeatability of thickness measurements of the posterior coat of the eye (sclera, choroid, and retina) in eyes with nAMD using a range of imaging modalities. All subjects provided informed written consent prior to study inclusion. The study was approved by the local research ethics committee (NRES Committee South East Coast–Surrey) and adhered to the tenets set
Patient Characteristics
Forty patients were included in the analyses (Table 1). All images were acquired between February 4, 2014 and July 7, 2014. The mean age (± SD) of the patients was 74.1 (± 7.2) years. There were 24 male and 16 female subjects. Eighteen left eyes and 22 right eyes were included in the study. The mean BCVA (± SD) was 64.4 (± 18.6) ETDRS letters. Thirty-eight of the 40 subjects (95%) had undergone treatment with intravitreous antiangiogenic agents in the previous 6 months.
Retinal and Choroidal Thickness Measurements
The mean (± SD) automated
Discussion
SDOCT-derived macular thickness and volume data are used in both clinical practice and research domains to identify macular disease progression or improvement, to determine the efficacy of macular treatments, to guide further treatment, and as an endpoint in clinical trials.23, 24, 25, 26 It is imperative, therefore, to understand the repeatability of SDOCT-derived macular thickness variables in patients with nAMD in order to distinguish true clinical change from measurement variability.
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Reply
2016, American Journal of OphthalmologyDiurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration
2023, International Journal of Retina and VitreousWeekly changes in axial length and choroidal thickness in children during and following orthokeratology treatment with different compression factors
2019, Translational Vision Science and Technology
Supplemental Material available at AJO.com.