Original articleThe Association of Blood Pressure and Primary Open-Angle Glaucoma: A Meta-analysis
Section snippets
Search Strategy
Our systematic review and meta-analysis was conducted according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines.26 To identify relevant studies, we searched MEDLINE and EMBASE for observational studies investigating the relation of BP or hypertension with POAG, IOP, or ocular hypertension (OHT), with no restrictions on language or publication date. The search period was through April 2013. Keywords included systolic blood pressure, diastolic blood pressure,
Study Characteristics
We identified 60 studies (44 cross-sectional, 9 case-control, and 7 longitudinal cohort studies) that met our inclusion criteria (Figure 1, Supplementary Table 1, available at AJO.com). Twenty-six studies were performed in Asia, 13 in the United States, 9 in Europe, 3 in the West Indies, 3 in Australia, 3 in Canada, 2 in the Middle East, and 1 in Congo. The prevalence of POAG in cross-sectional studies ranged from 0.7% to 9%. The number of studies that presented quantitative estimates and 95%
Discussion
In this comprehensive meta-analysis, hypertension and increased SBP and DBP were consistently associated with increased IOP across published studies. Hypertension was also positively associated with the risk of POAG, although the association was significant in cross-sectional but not in case-control or longitudinal studies. The dose-response relationship between SBP and DBP and the risk of glaucoma was also positive but weak. On the other hand, our findings support a role of increased BP in
Di Zhao, MHS is a PhD student in Epidemiology at the Johns Hopkins University Bloomberg School of Public Health. Her primary interest is in population based chronic disease research and in investigating risk factors associated with intraocular pressure, glaucoma and other eye diseases.
References (53)
- et al.
Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study
Ophthalmology
(2013) - et al.
The eye in hypertension
Lancet
(2007) - et al.
Blood Flow in Glaucoma Discussion. Blood pressure, perfusion pressure, and glaucoma
Am J Ophthalmol
(2010) - et al.
Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population: the Beijing Eye Study
Ophthalmology
(2009) - et al.
Retinal vessel diameter and open-angle glaucoma: the Blue Mountains Eye Study
Ophthalmology
(2005) - et al.
Long-term physiologic changes of intraocular pressure: a 10-year longitudinal analysis in young and middle-aged Japanese men
Ophthalmology
(2005) - et al.
Association of life-style with intraocular pressure in middle-aged and older Japanese residents
Jpn J Ophthalmol
(2003) - et al.
Risk factors for open-angle glaucoma: a case-control study
J Clin Epidemiol
(2001) - et al.
Risk factors for primary open angle glaucoma
Am J Prev Med
(1988) - et al.
Risk factors for incident open-angle glaucoma: the Barbados Eye Studies
Ophthalmology
(2008)
Relationships among systemic blood pressure, intraocular pressure, and open-angle glaucoma
Can J Ophthalmol
Hypertension, diabetes, and longitudinal changes in intraocular pressure
Ophthalmology
Intraocular pressure correlated with arterial blood pressure: the Beijing Eye Study
Am J Ophthalmol
Effect of CS-088, an angiotensin AT1 receptor antagonist, on intraocular pressure in glaucomatous monkey eyes
Exp Eye Res
The impact of ocular blood flow in glaucoma
Prog Retin Eye Res
Primary open-angle glaucoma, intraocular pressure, and systemic blood pressure in the general elderly population. The Rotterdam Study
Ophthalmology
Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders
Am J Ophthalmol
Ambulatory blood pressure monitoring in glaucoma. The nocturnal dip
Ophthalmology
Retinal autoregulation in open-angle glaucoma
Ophthalmology
Use of calcium channel blockers for glaucoma
Prog Retin Eye Res
Predictors of long-term progression in the Early Manifest Glaucoma Trial
Ophthalmology
Intraocular pressure
Contin Educ Anaesth Crit Care Pain
The non-contact tonometer. Its value and limitations
Surv Ophthalmol
The number of people with glaucoma worldwide in 2010 and 2020
Br J Ophthalmol
Central corneal thickness and correlation to optic disc size: a potential link for susceptibility to glaucoma
Br J Ophthalmol
High myopia as a risk factor in primary open angle glaucoma
Int J Ophthalmol
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Di Zhao, MHS is a PhD student in Epidemiology at the Johns Hopkins University Bloomberg School of Public Health. Her primary interest is in population based chronic disease research and in investigating risk factors associated with intraocular pressure, glaucoma and other eye diseases.
Supplemental Material available at AJO.com.