Original articleRelationship of Retinal Vascular Caliber with Optic Disc and Macular Structure
Section snippets
Study Population
This cross-sectional study was on a subset of participants from the Singapore Cohort Study of Risk Factors for Myopia (SCORM), which examined 1,979 children aged 7 to 9 years at baseline in 1999 and thereafter yearly in 3 schools in Singapore. The study methodology and details of the study population have been described in detail elsewhere.11, 12 The main exclusion criteria included significant systemic illnesses and ocular conditions including media opacity, uveitis, or a history of
Results
The mean age of the subjects included in the study was 11.51 ± 0.52 years, half were male, and the mean CRAE and CRVE were 154.05 ± 10.87 μm and 230.32 ± 16.26 μm, respectively. The mean spherical equivalent refraction was 0.46 ± 0.48 diopters and the mean AL was 22.86 ± 0.69 mm. Compared to excluded children (n = 590), children included in the study (n = 104) were more likely to be Chinese and younger. (11.51 ± 0.52 years vs 12.21 ± 1.12 years; P < .001) (data not shown).
Table 1 summarizes the
Discussion
Our study in a population sample of healthy school-aged Chinese children demonstrates significant correlations between retinal vascular caliber and different optic disc, RNFL, and macular features as measured by OCT. Given the high reliability and reproducibility of both of these imaging modalities,23, 24, 25, 26 and the absence of ocular or systemic disease in the study population, our findings likely represent physiologic relationships with a high degree of validity. We found that thinner
References (39)
- et al.
Retinal vessel diameter and open-angle glaucoma: the Blue Mountains Eye Study
Ophthalmology
(2005) - et al.
Retinal vascular caliber: systemic, environmental, and genetic associations
Surv Ophthalmol
(2009) - et al.
Influence of intraocular pressure on retinal vascular caliber measurements in children
Am J Ophthalmol
(2007) - et al.
Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study
Ophthalmology
(1999) - et al.
Does refractive error influence the association of blood pressure and retinal vessel diameters?The Blue Mountains Eye Study
Am J Ophthalmol
(2004) - et al.
Nearwork and myopia in young children
Lancet
(2001) - et al.
Retinal image analysis: concepts, applications and potential
Prog Retin Eye Res
(2006) Optic disk risk factors for nonarteritic anterior ischemic optic neuropathy
Am J Ophthalmol
(1993)- et al.
Anterior ischemic optic neuropathyIX. Cup-to-disc ratio and its role in pathogenesis
Ophthalmology
(1987) - et al.
How large is the optic disc?Systematic errors in fundus cameras and topographers
Ophthalmic Physiol Opt
(2001)