The relation of retinal microvascular characteristics to age-related eye disease: the Beaver Dam eye study☆
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Population
Methods used to identify and describe the population have appeared in previous reports.10, 11, 12, 13, 14 All data were collected with institutional review board approval in conformity with all country, federal, and state laws, and the study is in adherence with the tenets of the Declaration of Helsinki. In brief, a private census of the population of Beaver Dam, Wisconsin, was performed from September 15, 1987, to May 4, 1988, to identify all residents in the city or township of Beaver Dam who
Characteristics of the cohort
Characteristics of the cohort at baseline are presented in Table 1. The mean age was 62.0 years, the mean arterial blood pressure was 95.6 mm Hg, 970 (19.7%) of the cohort were current smokers, and 117 (2.4%) were heavy drinkers at baseline. Arteriovenous nicking was present in 68 (1.4%) and focal retinal arteriolar narrowing in 492 (10.2%) of the whole cohort. Retinopathy was present in 342 (7.8%) of those without diabetes. Early ARM was present in 890 (18.9%) and late ARM in 79 (1.7%).
Discussion
The data reported herein are unique in describing information regarding the associations of retinal microvascular disease (generalized and focal retinal arteriolar narrowing, venular dilation, and A/V nicking and retinopathy) and their associations with three age-related ocular diseases (ARM, cataract, and glaucoma) in a population-based cohort. A new computer-assisted grading technique based on measurements of individual retinal arteriolar and venular diameters from digitized photographs was
Supplementary files
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The study was supported by National Institutes of Health (Bethesda, MD) Grant No. EY06594 (R. Klein, BEK Klein) and, in part, by Research to Prevent Blindness (R. Klein, Senior Scientific Investigator Award), New York, NY.
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