Epidemiologic Characteristics, Predisposing Factors, and Etiologic Diagnosis of Corneal Ulceration in Nepal
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Urgent unmet needs in the care of bacterial keratitis: An evidence-based synthesis
2023, Ocular SurfaceCitation Excerpt :A systematic dissection of existing BK management approaches is required to explain why so many patients experience poor visual outcomes, and at frequencies that do not seem to be improving over time. Every clinical decision that is made in the care of BK carries the weight of the clinical axiom, “time equals vision”, because any delay to appropriate treatment is associated with worse outcomes [128–130]. The care of BK consists of a series of clinical decisions that are often made in the absence of important clinical data, such as when microbiology cultures are unrevealing.
Atypical microbial keratitis
2023, Ocular SurfaceCitation Excerpt :Being prevalent in the soil of South Asia [93], studies from the Indian subcontinent have reported Nocardia to cause 1.7–8.3% of bacterial keratitis [4,5]. Another study from Nepal reported that Nocardia accounted for 0.3% of all culture positive bacterial keratitis [94]. Outside the Asian continent however, Nocardia keratitis is rarely observed [95].
Advances in nanotherapies in the management of microbial keratitis
2023, Nanotechnology in OphthalmologyParadox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis
2022, Progress in Retinal and Eye ResearchCitation Excerpt :In some cases, retrocorneal fibrin deposition is also seen (Fig. 11). Loss of stromal tissue in S. pneumoniae ulcers may lead to formation of radiating folds in Descemet's membrane (Asbell and Stenson, 1982; Srinivasan et al., 1997; Upadhyay et al., 1991). S. viridans keratitis is associated with crystalline keratopathy, which are needle-like branching crystalline opacities within the corneal stroma without significant corneal or anterior segment inflammation, and is typically seen in postkeratoplasty infections. (
This study was supported by a grant from the International Development Research Center, Ottawa, Canada, in collaboration with the Department of Microbiology, University of Calgary, Calgary, Canada, and by assistance from the Francis I. Proctor Foundation and the Albert and Lotte Haas Foundation, San Francisco, California.
Reprint requests to Madan P. Upadhyay, M.D., Tribhuvan University, Institute of Medicine, Box 2162, Kathmandu, Nepal; or John P. Whitcher, M.D., Francis I. Proctor Foundation, 95 Kirkham St., San Francisco, CA 94143-0944.