Ultrasound Biomicroscopy of Anterior Segment Structures in Normal and Glaucomatous Eyes

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We developed a new method of imaging the anterior segment of the eye using high-frequency ultrasound that allows structural details of the angle, iris, ciliary body, zonule, and posterior chamber to be visualized and measured at microscopic resolution in living patients. We applied the term ultrasound biomicroscopy to this technique, which we used to image anterior segment structures in a series of nine normal subjects. We provide a system of definition for anterior segment measurements that will allow reproducible measurements to be performed in the future. Measurements in normal subjects provide a foundation for future studies of specific glaucoma types and facilitate comparison of normal and glaucomatous eyes. Images in several specific types of glaucoma were obtained to exemplify the potential of this technique.

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This study was supported by the National Cancer Institute of Canada and the Ontario Cancer Research and Treatment Foundation, Toronto, Ontario, Canada. Dr. Foster is a Senior Research Scholar of the National Cancer Institute of Canada.

Reprint requests to Charles J. Pavlin, M.D., Ocular Oncology Clinic, Princess Margaret Hospital, 500 Sherbourne St., Toronto, Ontario, Canada M4X 1K9.

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