Changes in the Extracellular Matrix of the Human Optic Nerve Head in Primary Open-Angle Glaucoma
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2021, Ophthalmology GlaucomaCitation Excerpt :Acute IOP changes lead to changes in PLT thickness,30,31 whereas we evaluated the effects of chronic elevation of IOP on LC and PLT in eyes receiving medical treatment with no history of glaucoma surgery. In patients with chronically elevated IOP, the PLT is under constant stress and strain, leading to extracellular matrix remodeling.32–34 In advanced glaucoma patients, laminar compliance is decreased because of decreased retinal ganglion cell axons and increased tissue stiffness resulting from tissue remodeling.26
The extracellular matrix composition of the optic nerve subarachnoid space
2020, Experimental Eye Research
Reprint requests to M. Rosario Hernandez, D.D.S., Eye Research Institute, 20 Staniford St., Boston, MA 02114.
This study was supported in part by National Eye Institute research grant EY-06416, the New England Glaucoma Research Foundation, Inc. (Boston), the Glaucoma Foundation (New York), and the Foundation for Glaucoma Research (San Francisco).