Rate of visual field loss and long-term visual outcome in primary open-angle glaucoma☆
Section snippets
Methods
In this cohort study, a retrospective chart review was performed on patients with primary open-angle glaucoma who had been followed in the Vascular and Glaucoma Services of the Department of Ophthalmology and Visual Sciences at the University of Iowa since 1972.
The inclusion criteria were as follows: (1) Diagnosis of primary open-angle glaucoma with elevated intraocular pressure as defined by the age of onset 40 years or older, normal-appearing (open) iridocorneal angles, peak intraocular
Results
Forty eyes of 40 patients with primary open-angle glaucoma satisfied our study inclusion and exclusion criteria. Characteristics of patients on initial presentation are shown in Table 1. All patients were Caucasian, reflecting the underlying population demographics of Iowa (98% Caucasian). The average age of patients was 64.3 ± 8.3 years (range, 40 to 84). Eleven eyes had mild cataract on presentation (average cataract score of 1.5) in addition to primary open-angle glaucoma. Coexistent ocular
Discussion
We have presented the long-term clinical outcome (average of 14 years) in a group of primary open-angle glaucoma eyes meeting our inclusion and exclusion criteria. The results indicate the average Goldmann visual field decline is slow, at −1.5% per year for all eyes, and −2.1% per year for the 68% of eyes that showed significant decline. Recently, Rasker and associates6 reported a similar study using an automated perimetry (Peritest, Rodenstock, Munich, Germany) with a mean follow-up of 8
References (17)
- et al.
The effect of aspirin on the visual outcome of nonarteritic anterior ischemic optic neuropathy
Am J Ophthalmol
(1996) - et al.
The probability of blindness from open-angle glaucoma
Ophthalmology
(1998) - et al.
Intraocular pressure and the rate of visual field loss in chronic open-angle glaucoma
Am J Ophthalmol
(1991) - et al.
The onset and evolution of glaucomatous visual field defects
Ophthalmology
(1982) - et al.
The rate of progression of scotomas in glaucoma
Am J Ophthalmol
(1986) - et al.
Estimating progression of visual field loss in glaucoma
Ophthalmology
(1997) - et al.
Rate of progression in open-angle glaucoma estimated from cross-sectional prevalence of visual field damage
Am J Ophthalmol
(1996) - et al.
Why do some people go blind from glaucoma?
Ophthalmology
(1982)
Cited by (120)
The nitric oxide-guanylate cyclase pathway and glaucoma
2018, Nitric Oxide - Biology and ChemistryComparing Treatment of Acute Retinal Necrosis With Either Oral Valacyclovir or Intravenous Acyclovir
2018, American Journal of OphthalmologyDistribution and Rates of Visual Field Loss across Different Disease Stages in Primary Open-Angle Glaucoma
2018, Ophthalmology GlaucomaCitation Excerpt :Because of different vulnerabilities of ganglion cells, the pathophysiology of any patterns of POAG could be different. The rate of VF loss in POAG eyes has been studied by different groups;24–35 however, a comprehensive analysis presenting both patterns and rates of VF loss of POAG eyes using a large cohort with long-term follow-ups has been lacking. We found that the rate of VF loss was faster in eyes at the early stage than in the moderate stage of glaucoma (−0.2 dB/year and −0.12 dB/year, respectively; P = 0.02).
Immunomodulatory and Antioxidant Drugs in Glaucoma Treatment
2023, Pharmaceuticals
- ☆
This work was supported in part by the Shaffer International Research Fellowship from the Glaucoma Research Foundation, San Francisco, California, an unrestricted grant from Research to Prevent Blindness, New York, New York, and National Eye Institute research grants EY-1151 and EY-3330. Dr Hayreh is a Research to Prevent Blindness Senior Scientific Investigator.