Studies on the mechanism of phospholipid storage induced by amantadine and chloroquine in Madin Darby canine kidney cells
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Evaluation and validation of multiple cell lines and primary mouse macrophages to predict phospholipidosis potential
2011, Toxicology in VitroCitation Excerpt :Drug-induced PLD is generally associated with amine-containing cationic amphiphilic drugs (CADs) that are protonated and trapped in the acidic milieu of lysosomes causing significant tissue accumulation of drug (Kaufmann and Krise, 2007; Yokogawa et al., 2002). Although the molecular mechanism for PLD is not fully established, binding of CADs to lysosomal lipids can interfere with phospholipase activity by disrupting membrane fluidity (Grabner, 1987) or decreasing enzymatic activity, as has been demonstrated with phospholipase A, C, (Hostetler and Matsuzawa, 1981; Hostetler and Richman, 1982; Matsuzawa and Hostetler, 1980) and sphingomyelinase (Yoshida et al., 1985). A mouse model for sphingomyelinase deficiency or Niemann–Pick disease (Nakashima et al., 1984) accumulate sphingomyelin in target organs resulting in lesions that are characteristically reminiscent of PLD.
Effect of co-administration of fluoxetine and amantadine on immunoendocrine parameters in rats subjected to a forced swimming test
2009, Pharmacological ReportsCitation Excerpt :Indeed, treatment of isolated mouse spleen T cells, but not accessory cells, with AMA inhibited the proliferative response to Con A. Moreover, it was demonstrated that AMA affected CD8+ cells (suppressor/cytotoxic cells), but had no effect on CD4+ ones [9]. The possible AMA-mediated modes of action on the cascade of events involved in the activation and proliferation of T lymphocytes are: a) the hydrophobic bonding of AMA to membrane lipids (steric modification of cellular receptors), and b) the inhibitory activity of AMA on protein synthesis, phospholipid metabolism [8] and soluble phos-pholipases A and C [28]. In vitro studies have shown a direct inhibitory effect of AMA (used in relatively high doses) on lymphocyte proliferation [10].
Cell-based fluorescence assay for evaluation of new-drugs potential for phospholipidosis in an early stage of drug development
2007, Experimental and Toxicologic PathologyIatrogenic Phospholipidosis Mimicking Fabry Disease
2006, American Journal of Kidney DiseasesCitation Excerpt :Iatrogenic phospholipidosis has been reported in association with several drugs; the most common are chloroquine and amiodarone.14-16 Chloroquine is a weak base that becomes concentrated within lysosomes and inhibits key lysosomal enzymes, including α-galactosidase A, in addition to cathepsin, acid hydrolase, and phospholipases.14,17-22 Because of similarities in chemical structure, it is reasonable to assume that hydroxychloroquine causes iatrogenic phospholipidosis in a manner similar to chloroquine.
Chloroquine-induced lipidosis mimicking Fabry disease
2005, Modern PathologyChloroquine-induced phospholipidosis of the kidney mimicking fabry's disease: Case report and review of the literature
2003, Human PathologyCitation Excerpt :The resulting increase in lysosomal pH is an important mechanism in the inactivation of lysosomal enzymes and impairment of degradative capacity.33-35 Chloroquine thereby inhibits the activity of various enzymes, including cathepsin, acid hydrolase,36-38 phospholipase,39,40 and other lysosomal enzymes,41 and also of transport ATPases42 and glutamate-dehydrogenase.43 Chloroquine has also been reported to induce morphological and functional changes in mitochondria.44