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Time course of changes in contrast sensitivity following intravitreal ranibizumab injection for branch retinal vein occlusion

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate contrast sensitivity (CS) in patients with branch retinal vein occlusion (BRVO) following intravitreal ranibizumab injection (IVR), and to investigate the relationship between CS and retinal microstructure.

Design

A retrospective, observational case series.

Methods

We included 23 eyes with treatment naïve BRVO followed up for 6 months after treatment. Best-corrected visual acuity (BCVA), letter contrast sensitivity (LC), and 10% low contrast visual acuity (LCVA) were measured. All tests were performed before and 1, 2, 3, 4, 5, and 6 months after treatment. Based on optical coherence tomography (OCT) images, we assessed central retinal thickness (CRT), presence of serous retinal detachment (SRD), and status of the external limiting membrane (ELM) and ellipsoid zone (EZ).

Results

IVR treatment significantly improved CS (LC: P < 0.0001, LCVA: P = 0.004) as well as BCVA (P = 0.015) and CRT (P < 0.0001). LC and LCVA at 6 months after treatment were significantly correlated with presence of SRD before treatment. At 6 months after treatment, LCVA was significantly correlated with pre-treatment CRT (P = 0.042). In patients with good baseline BCVA, LCVA showed significant improvements (P = 0.022) although their BCVA did not change. In patients with poor improvement in BCVA, LC and LCVA also showed significant improvements (P = 0.008, P = 0.005).

Conclusion

IVR treatment for BRVO improves both BCVA and CS. Even in patients without any improvement in visual acuity, CS does improve.

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan

    Yoshimi Sugiura, Fumiki Okamoto, Tomoya Murakami, Shohei Morikawa, Takahiro Hiraoka & Tetsuro Oshika

Authors
  1. Yoshimi Sugiura
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  2. Fumiki Okamoto
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  3. Tomoya Murakami
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  4. Shohei Morikawa
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  5. Takahiro Hiraoka
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  6. Tetsuro Oshika
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Contributions

Conception and Design of the study: YS, FO; Analysis and interpretation: YS, TO; Writing the article: YS, FO; Critical revision of the article: TM, SM, TH, TO; Final approval of the article: YS, FO, TM, SM, TH, TO; Data collection: YS, TM, SM, TH.

Corresponding author

Correspondence to Yoshimi Sugiura.

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Conflicts of interest

Y. Sugiura, None; F. Okamoto, None; T. Murakami, None; S. Morikawa, None; T. Hiraoka, None; T. Oshika, None.

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Corresponding Author: Yoshimi Sugiura

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Sugiura, Y., Okamoto, F., Murakami, T. et al. Time course of changes in contrast sensitivity following intravitreal ranibizumab injection for branch retinal vein occlusion. Jpn J Ophthalmol 64, 497–505 (2020). https://doi.org/10.1007/s10384-020-00758-9

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  • DOI: https://doi.org/10.1007/s10384-020-00758-9

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