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Mucosa-associated lymphoid tissue lymphoma in the conjunctiva of a child

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Abstract

Marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) occurring in the conjunctiva has yet not been described in pediatric patients. We present a case of a 10-year-old girl with a MALT lymphoma involving the conjunctiva. The tumor consisted of plasma cells and marginal zone cells with discrete epitheliotropism. Immunohistochemical studies revealed positivity for CD20 and cytoplasmic immunoglobulin λ light chain restriction. Polymerase chain reaction-based molecular analysis of the infiltrate showed a monoclonal rearrangement for the hypervariable complimentary determining region III immunoglobulin region; whereas, a polyclonal pattern was seen for the T-cell receptor γ chain. Extensive further examination, including molecular techniques, revealed that the lymphoma was restricted to the conjunctiva (stage IA) and was not associated with any specific infection. The patient was treated with surgery and additional local cryotherapy. After 15 months of follow-up, the patient remains in complete remission.

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Fig. 1 A
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Authors and Affiliations

  1. Department of Hematopathology, University of Kiel, Niemannsweg 11, 24105 , Kiel, Germany

    Markus Tiemann

  2. Department of Pediatrics, University of Kiel, Schwanenweg 20, 24105 , Kiel, Germany

    Marcus Heidemann & Alexander Claviez

  3. Department Ophthalmology, University of Kiel, Hegewischstraße 2, 24105 , Kiel, Germany

    Steffi Häring & Jan Reichelt

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  1. Markus Tiemann
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  2. Steffi Häring
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  5. Alexander Claviez
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Correspondence to Markus Tiemann.

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Tiemann, M., Häring, S., Heidemann, M. et al. Mucosa-associated lymphoid tissue lymphoma in the conjunctiva of a child. Virchows Arch 444, 198–201 (2004). https://doi.org/10.1007/s00428-003-0919-7

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  • DOI: https://doi.org/10.1007/s00428-003-0919-7

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