Table 3

Results of replication of five of the six SNPs showing linkage to response (p<0.01) in the discovery cohort. Shown are results from the association between SNP genotype and change in BCVA (logMAR) after 3 months, as assessed using a linear model correcting for age and gender. Negative beta values indicate that the SNP is associated with a decreased vision. Also indicated is the direction of risk change in the discovery cohort, with increased and decreased corresponding to a higher and lower risk not to respond to anti-VEGF treatment, respectively. P values were not corrected for multiple testing

SNPGenotypeRisk in discovery cohortBetaSEP value
  • BCVA, best corrected visual acuity; SNP, single nucleotide polymorphism; VEGF, vascular endothelial growth factor.