Table 3

Results of replication of five of the six SNPs showing linkage to response (p<0.01) in the discovery cohort. Shown are results from the association between SNP genotype and change in BCVA (logMAR) after 3 months, as assessed using a linear model correcting for age and gender. Negative beta values indicate that the SNP is associated with a decreased vision. Also indicated is the direction of risk change in the discovery cohort, with increased and decreased corresponding to a higher and lower risk not to respond to anti-VEGF treatment, respectively. P values were not corrected for multiple testing

SNPGenotypeRisk in discovery cohortBetaSEP value
rs17086609GenotypedIncreased−0.0120.0220.59
rs2046462ImputedIncreased−0.0530.0220.019
rs7691507GenotypedIncreased−0.0520.0400.19
rs12054587ImputedDecreased0.0190.0330.56
rs3775194ImputedDecreased0.0190.0270.49
  • BCVA, best corrected visual acuity; SNP, single nucleotide polymorphism; VEGF, vascular endothelial growth factor.