Potential predictors of early visual improvement in RIDE and RISE
| Baseline patient characteristics/demographics | Targeted medical histories |
| Age | Hypertension |
| Race and ethnicity | Proteinuria |
| Sex | Rheumatoid arthritis |
| Current smoker | Any neovascular condition |
| Oedema type (focal/diffuse/absent, NA or unknown) | Any cardiovascular condition |
| Prior DME therapy | Glaucoma in study eye |
| BCVA (≤55 vs >55 ETDRS letters) | Dermatitis |
| Proliferative diabetic retinopathy | Any clotting/bleeding condition |
| Central foveal thickness | Renal failure |
| Presence of subretinal fluid | Diverticular disease |
| Chronic kidney disease (eGFR <60 mL/min/1.73 m2) | |
| Duration of diabetes at randomisation | |
| HbA1c | |
| Bilateral DME | |
| Insulin use | |
| Systolic blood pressure | |
| Diastolic blood pressure | |
| Intraocular pressure |
BCVA, best-corrected visual acuity; DME, diabetic macular oedema; eGFR, estimated glomerular filtration rate; ETDRS, Early Treatment Diabetic Retinopathy Study; HbA1c, glycated haemoglobin; NA, not applicable.