Table 6

Multivariate analysis

Multivariate analysis of patients with random effects
Coefficient (95% CI)P value
Multivariate analysis
ECL~CDE+fluid+operation method+preoperative ECD
CDE36.2 (35.6 to 36.9)1.319×10 12*
Preoperative ECD0.193 (0.182 to 0.203)0.0056*
Univariate analysis
Operation method106 (98.14 to 113.74)0.044*
Cataract grade I376.5 (360.0 to 392.96)
Cataract grade II394.67 (377.3 to 415.0)0.875
Cataract grade III515.39 (495 to 535)0.305
Cataract grade IIII298.57 (256.86 to 340.28)0.781
Surgery time17.22 (15.39 to 19.04)0.161
Preoperative endothelial cell density0.21 (0.195 to 0.222)0.023*
Fluid use5.545 (5.29 to 5.80)0.00163*
CDE35.498 (34.8 to 36.1)5.21×10 13*
  • We performed a multivariate analysis with patients with random effects to examine the impact of CDE, fluid use, operation method and preoperative ECD on ECL. We found that CDE is the main contributor to ECL and that preoperative ECD is significant for the amount of ECL. In the univariate model, we found that fluid use and operation method contribute to ECL.

  • *Statistically significant.

  • †Cataract grade I serves as a reference to the other cataract grades.

  • CDE, cumulative dissipated energy; CPS, conventional phaco surgery; ECD, endothelial cell density; ECL, endothelial cell loss; FLACS, femtosecond laser-assisted cataract surgery.