Associations with high TIMP-2 presented for three models
| High TIMP-2 (≥205 ng/mL) | |||||||||
| Model 1 | Model 2 | Model 3 | |||||||
| COR (95% CI) | P value | AOR (95% CI) | P value a | AOR (95% CI) | P value b | AOR (95% CI) | P value c | ||
| Sex | (women) | 1.4 (0.8 to 2.5) | 0.21 | – | – | – | – | – | – |
| Age (per year) | 1.04 (1.02 to 1.07) | 0.001 | – | – | – | – | 1.02 (0.98 to 1.05) | 0.32 | |
| Diabetes duration (per year) | 1.05 (1.03 to 1.08) | <0.001 | – | – | – | – | 1.05 (1.02 to 1.08) | <0.001 | |
| DR | Proliferative | 2.4 (1.1 to 5.4) | 0.036 | 2.2 (0.9 to 5.4) | 0.08 | – | – | ||
| Severe non-proliferative | 1.4 (0.5 to 3.8) | 0.50 | 1.4 (0.5 to 4.0) | 0.53 | – | – | |||
| Moderate non-proliferative | 1.8 (0.8 to 4.0) | 0.12 | 2.0 (0.9 to 4.5) | 0.10 | – | – | |||
| Mild non-proliferative | 0.5 (0.2 to 1.4) | 0.18 | 0.6 (0.2 to 1.7) | 0.34 | – | – | |||
| No apparent | 1 | 1 | – | – | – | ||||
| DR, at least moderate | 2.5 (1.4 to 4.4) | 0.002 | – | – | 2.3 (1.2 to 4.3) | 0.009 | 1.3 (0.6 to 2.7) | 0.52 | |
| Macroalbuminuria | 4.9 (1.7 to 14.4) | 0.004 | 3.4 (1.1 to 10.5) | 0.032 | 3.4 (1.1 to 10.2) | 0.031 | 3.7 (1.2 to 11.3) | 0.022 | |
| Antihypertensive drugs | 2.1 (1.2 to 3.7) | 0.012 | – | – | – | – | 1.0 (0.5 to 2.0) | 0.98 | |
.a, b, c Multiple logistic regression (Backward Wald): n = a, b, c 250; Nagelkerke R Square a 0.10/b 0.09/c 0.13.
AOR, adjusted OR; COR, crude OR; DR, diabetic retinopathy; TIMP-2, tissue inhibitor of metalloproteinase-2.