Table 1

Inclusion and exclusion criteria of ROMIO and TO-SEE studies8 9

Inclusion criteriaExclusion criteria
ROMIO

  • 6–10 years (inclusive)

  • Myopia: between 0.50 D and 4.00 D in at least one eye

  • Astigmatism:<1.50 D; with-the-rule astigmatism (axes 180±30) ≤1.25 D; astigmatism of other axes ≤0.50 D in both eyes

  • Spherical equivalent (SE):>0.50 D and ≤4.50 D in both eyes

  • Anisometropia:≤1.50 D

  • Best-corrected logMAR visual acuity 0.10 or better in both eyes

  • Symmetrical corneal topography with corneal toricity <2.00 D in either eye

ROMIO and TO-SEE

  • Strabismus at distance or near

  • Previous experience in contact lens wear or myopia control treatment (eg, refractive therapy or progressive spectacles)

  • Contraindication for contact lens wear and orthokeratology (eg, limbus to limbus corneal cylinder and dislocated corneal apex)

  • Previous history of ocular surgery, trauma or chronic ocular disease

  • Concurrent use of medications that may affect tear quality

  • Systemic or ocular conditions that may affect tear quality or contact lens wear (eg, allergy and concurrent medication) or that may affect refractive development (eg, Down syndrome, ptosis)

  • Poor compliance to tests (eg, poor fixation in noncontact tonometry or intolerance of lens wear)

  • Not willing to comply with the allocated treatment and follow-up schedule

TO-SEE

  • 6–12 years (inclusive)

  • Myopia: between 0.50 D to 5.00 D

  • Astigmatism (with-the-rule astigmatism): 1.25–3.50 D; (axes 180±20)

  • Anisometropia: ≤1.50 D

  • Best-corrected logMAR visual acuity 0.10 or better in both eyes

  • logMAR, logarithm of the minimum angle of resolution.