Table 3

Results of meta-analysis in OCTA

Area	Parameter	Comparison	Overall effect		Heterogeneity
Area	Parameter	Comparison	Mean difference (95% CI)	P value	I² test (%)	Q test (P)
ONH-VD	Overall	HC versus non-DON	−1.94 (−3.56 to −0.32)	0.02	73	0.03
		HC versus DON	−5.01 (−6.85 to −3.17)	0.00	57	0.10
		non-DON versus DON	−3.10 (−4.32 to −1.88)	0.00	0	0.81
	Inside disc	HC versus non-DON	−1.22 (−4.61 to 2.16)	0.48	84	0.002
		HC versus DON	−3.97 (−7.70 to −0.24)	0.04	76	0.01
		non-DON versus DON	−2.70 (−4.54 to −0.87)	0.004	0	0.92
	Peripapillary	HC versus non-DON	−3.01 (−6.34 to 0.33)	0.08	91	0.00
		HC versus DON	−4.97 (−6.91 to −3.03)	0.00	43	0.17
		non-DON versus DON	−3.15 (−4.59 to −1.71)	0.00	0	0.91
RPC-VD	Overall	HC versus non-DON	−1.23 (−1.92 to −0.54)	0.00	56	0.08
		HC versus DON	−10.07 (−18.08 to −2.07)	0.01	97	0.00
		non-DON versus DON	−6.17 (−10.65 to −1.70)	0.007	96	0.00
	Inside disc	HC versus non-DON	−2.50 (−4.29 to −0.71)	0.006	49	0.14
		HC versus DON	−6.91 (−11.27 to −2.54)	0.002	64	0.09
		non-DON versus DON	−1.13 (−2.73 to 0.46)	0.08	30	0.24
	Peripapillary	HC versus non-DON	−1.16 (−2.24 to −0.08)	0.04	65	0.06
		HC versus DON	−4.64 (−7.85 to −1.43)	0.005	73	0.05
		non-DON versus DON	−2.07 (−3.97 to −0.16)	0.03	76	0.02
	Superior-hemi	HC versus non-DON	−0.78 (−1.02 to −0.54)	0.00	0	0.38
		HC versus DON	−4.21 (−6.80 to −1.61)	0.001	50	0.16
		non-DON versus DON	−1.82 (−3.30 to −0.34)	0.02	48	0.15
	Inferior-hemi	HC versus non-DON	−1.52 (−2.92 to −0.12)	0.03	74	0.02
		HC versus DON	−4.84 (−8.66 to −1.02)	0.01	74	0.05
		non-DON versus DON	−1.26 (−2.81 to 0.28)	0.11	48	0.15
	S	HC versus non-DON	−0.79 (−1.64 to 0.07)	0.00	14	0.28
		HC versus DON	−11.13 (−22.02 to −0.25)	0.05	96	0.00
		non-DON versus DON	−9.92 (−21.12 to 1.29)	0.08	96	0.00
	T	HC versus non-DON	−4.59 (−10.21 to 1.03)	0.11	89	0.003
		HC versus DON	−9.50 (−15.16 to −3.85)	0.001	96	0.00
		non-DON versus DON	−5.76 (−10.89 to −0.64)	0.03	94	0.00
	I	HC versus non-DON	−2.27 (−6.58 to 2.03)	0.30	87	0.006
		HC versus DON	−10.75 (−22.53 to 1.04)	0.07	97	0.00
		non-DON versus DON	−9.03 (−21.56 to 3.49)	0.16	97	0.00
	N	HC versus non-DON	−0.45 (−0.78 to −0.11)	0.01	0	0.82
		HC versus DON	−6.13 (−10.97 to −1.30)	0.01	93	0.00
		non-DON versus DON	−5.40 (−9.90 to −0.90)	0.02	92	0.00
RCL	M-SRCL	HC versus non-DON	−2.51 (−4.57 to −0.45)	0.02	76	0.04
		HC versus DON	−4.47 (−5.63 to −3.31)	0.00	0	0.55
		non-DON versus DON	−1.83 (−4.66 to 1.01)	0.21	76	0.04
	M-DRCL	HC versus non-DON	−2.10 (−4.87 to 0.66)	0.14	76	0.04
		HC versus DON	−4.19 (−10.22 to 1.84)	0.17	89	0.002
		non-DON versus DON	−1.72 (−3.49 to 0.05)	0.30	62	0.11

DON, dysthyroid optic neuropathy; HC, healthy control; I, inferior; Inferior-hemi, inferior hemifield; M-DRCL, macular deep retinal capillary layer; M-SRCL, macular superficial retinal capillary layer; N, nasal; non-DON, thyroid-associated ophthalmopathy without DON; OCTA, optical coherence tomography angiography; ONH-VD, optic nerve head vessel density; RCL, retinal capillary layer; RPC-VD, radial peripapillary capillary vessel density; S, superior; Superior-hemi, superior hemifield; T, temporal.