Table 2

Results of meta-analysis in OCT

AreaParameterComparisonOverall effectHeterogeneity
Mean difference (95% CI)P valueI² test (%)Q test (P)
PRNFLOverallHC versus non-DON−1.51 (−4.30 to 1.28)0.29730.005
HC versus DON−3.90 (−13.22 to 5.43)0.41960.00
non-DON versus DON−7.06 (−20.52 to 6.41)0.30970.00
Superior-hemiHC versus non-DON−0.62 (−5.28 to 4.03)0.79720.06
HC versus DON7.66 (−7.23 to 22.55)0.31830.02
non-DON versus DON3.84 (−9.14 to 16.81)0.56800.006
Inferior-hemiHC versus non-DON−4.03 (−11.25 to 3.19)0.27890.002
HC versus DON2.64 (−12.20 to 17.48)0.73870.006
non-DON versus DON1.93 (−9.93 to 13.79)0.75850.001
SHC versus non-DON−3.21 (−11.79 to 5.36)0.46840.007
HC versus DON−11.78 (−31.11 to 7.55)0.23940.00
non-DON versus DON−21.96 (−63.83 to 19.90)0.30970.00
THC versus non-DON−2.72 (−7.30 to 1.86)0.24550.11
HC versus DON−0.42 (−6.35 to 5.51)0.89770.002
non-DON versus DON−1.83 (−11.83 to 8.16)0.72700.03
IHC versus non-DON−4.27 (−11.21 to 2.67)0.23620.07
HC versus DON−11.73 (−30.35 to 6.90)0.22940.00
non-DON versus DON−21.48 (−65.23 to 22.26)0.34970.00
NHC versus non-DON−1.57 (−11.18 to 8.03)0.75880.00
HC versus DON−8.04 (−22.15 to 6.08)0.26960.00
non-DON versus DON−13.71 (−48.21 to 20.79)0.44980.39
MGCCLOverallHC versus non-DON0.29 (−0.39 to 0.97)0.41690.01
HC versus DON−3.15 (−3.74 to −2.56)0.00870.00
non-DON versus DON−7.27 (−10.80 to −3.74)0.00760.00
Superior-hemiHC versus non-DON0.02 (−0.75 to 0.80)0.95700.07
HC versus DON−3.38 (−4.09 to −2.66)0.00920.00
non-DON versus DON−7.30 (−12.84 to −1.76)0.01790.00
Inferior-hemiHC versus non-DON1.07 (0.26 to 1.87)0.009730.06
HC versus DON−2.22 (−2.77 to −1.68)0.00950.00
non-DON versus DON−9.07 (−16.56 to −1.59)0.02880.00
GCL+IPLOverallHC versus non-DON−4.42 (−5.81 to −3.03)0.000057
HC versus DON−9.41 (−11.76 to −7.06)0.0000.70
non-DON versus DON−4.95 (−7.42 to −2.48)0.0000.46
  • DON, dysthyroid optic neuropathy; GCL+IPL, ganglion cell layer and inner plexiform layer; HC, healthy control; I, inferior; Inferior-hemi, inferior hemifield; MGCCL, macular ganglion cell complex layer; N, nasal; non-DON, thyroid-associated ophthalmopathy without DON; OCT, optical coherence tomography; PRNFL, peripapillary retinal nerve fibre layer; S, superior; Superior-hemi, superior hemifield; T, temporal.