Table 1

Results of meta-analysis in main characteristics

ParameterComparisonOverall effectHeterogeneity
Mean difference (95% CI)P valueI² test, %Q test (P)
CASHC versus non-DONNANANANA
HC versus DONNANANANA
non-DON versus DON1.28 (0.65 to 1.90)0.00920.00
VAHC versus non-DON0.02 (−0.00 to 0.04)0.00900.05
HC versus DON0.39 (0.11 to 0.66)0.00940.00
non-DON versus DON0.32 (0.18 to 0.45)0.00900.00
ExophthalmosHC versus non-DONNANANANA
HC versus DONNANANANA
non-DON versus DON1.23 (0.69 to 1.77)0.0000.44
IOPHC versus non-DON2.92 (2.05 to 3.80)0.00620.02
HC versus DON6.20 (3.43 to 8.96)0.00870.00
non-DON versus DON2.46 (0.63 to 4.29)0.008790.00
VF-MD(dB)HC versus non-DON0.42 (−0.63 to 1.47)0.43920.00
HC versus DON−5.17 (−6.46 to −3.87)0.00700.07
non-DON versus DON−7.69 (−9.50 to −5.88)0.00910.00
VF-PSD(dB)HC versus non-DONNANANANA
HC versus DONNANANANA
non-DON versus DON3.80 (2.25 to 5.34)0.00950.00
  • CAS, clinical activity score; DON, dysthyroid optic neuropathy; HC, healthy control; IOP, intraocular pressure; non-DON, thyroid-associated ophthalmopathy without DON; VA, visual acuity; VF-MD, visual field mean deviation; VF-PSD, visual field pattern SD.