Univariate and multivariate analysis of the risk factors for optic atrophy by primary outcome
| Univariate analysis | Multivariate analysis | ||||
| OR (95% CI) | P value | OR (95% CI) | P value | ||
| Male sex | 0.83 (0.34 to 1.88) | 0.666 | |||
| IIH | 1.00 (0.47 to 2.11) | 0.996 | |||
| Haemorrhage | 33.17 (11.40 to 113.85) | p<0.001 | 19.12 (3.92 to 111.37) | p<0.001 | |
| VF damage* | 37.51 (10.97 to 176.88) | p<0.001 | |||
| VA≤20/25 | 25.76 (9.38 to 80.61) | p<0.001 | 7.76 (1.35 to 46.39) | 0.020 | |
| Initial GCL reach† | 35.67 (5.92 to 685.24) | 0.001 | 18.25 (1.94 to 416.59) | 0.021 | |
| Cephalees | 0.82 (0.35 to 2.01) | 0.646 | |||
| Visualblur | 1.79 (0.84 to 3.81) | 0.129 | |||
| Nausea/vomiting | 1.30 (0.60 to 2.78) | 0.495 | |||
| Diplopia‡ | 2.07 (0.85 to 4.85) | 0.098 | |||
| Tinnitus | 1.32 (0.28 to 4.73) | 0.687 | |||
| Eclipses | 2.61 (0.83 to 7.62) | 0.085 | |||
| Seizures | 4.26 (0.96 to 18.92) | 0.049 | |||
| Mean A | Mean NA | P value | OR (95% CI) | P value | |
| Age (years) | 24.57 | 22.04 | 0.997 | ||
| BMI (kg/m2†) | 25.72 | 28.09 | 0.061 | ||
| ICP (cmH20) | 36.40 | 43.57 | 0.042 | ||
| TR D0 (μm) | 483.72 | 796.69 | p<0.001 | 1.01 (1.01 to 1.02) | 0.001 |
| RNFL j0 (μm) | 199.63 | 365.28 | p<0.001 | ||
| Delay§ | 40.43 | 71.69 | 0.136 | ||
The bold values are the significant values (p < 0.05).
*Defined by a visual field impairment other than blind spot enlargement.
†Defined by an initial GCL at D0 lower than 1 mm3.
‡By paralysis of the VI nerve.
§Delay between the first symptoms and the diagnosis.
BMI, body mass index; GCL, ganglion cell layer; ICP, intracranial pressure; IIH, idiopathic intracranial hypertension; mean A/NA, mean in the atrophy/non-atrophy group; RNFL D0, retinal nerve fibre layer thickness at diagnosis; TR D0, total peripapillary retinal thickness at diagnosis; VA≤20/25, initial visual acuity less than or equal 20/25 on the Snellen scale; VF, visual field.