Baseline risk factors for RNFL progression rate | Eyes, n | RNFL rate of change in μm/year (95% CI)* | P value |

RNFL (per 10 μm increase) | 1004 | −0.59 (−0.67 to 0.50) | <0.0001 |

MD (per 1 dB increase) | 1004 | 0.02 (0.01 to 0.03) | 0.003 |

Beta peripapillary atrophy | |||

No | 128 | −1.58 (−1.68 to 1.47) | 0.03 |

Yes | 254 | −1.73 (−1.82 to 1.64) | |

Unknown | 622 | −1.63 (−1.72 to 1.54) |

Baseline risk factors for MD progression rate | Eyes, n | MD rate of change in dB/year (95% CI)† | P value |

BMI (per 10 kg/m^{2} increase) | 588 | 0.021 (0.009 to 0.033) | 0.0004 |

CDR (per 1 unit increase) | 588 | −0.046 (−0.085 to 0.007) | 0.02 |

MD (per 1 dB increase) | 588 | −0.060 (−0.0077 to 0.0044) | <0.0001 |

*From the multivariable linear regression model that included baseline RNFL, MD and beta peripapillary atrophy as predictors, and RNFL progression rate as the outcome variable. The analyses were restricted to 1004 eyes with baseline measurements for MD after the start of the RNFL observation period.

†From the multivariable linear regression model that included baseline BMI, CDR and MD as predictors, and MD progression rate as the outcome variable. The analyses were restricted to 588 eyes with baseline BMI, CDR and MD values.

RNFL, retinal nerve fibre layer; MD, mean deviation; BMI, body mass index; CDR, cup-to-disc ratio.;