Table 3

Multivariable analyses of baseline risks factors for being a fast structural progressor and a moderate/fast functional progressor

Baseline risk factors
Structural progression
Eyes, nEyes with fast structural progression, n, (%)Adjusted OR
(95% CI)*
P value
RNFL (per 10 μm increase)1424389 (27.3%)2.64 (2.34 to 2.98)<0.0001
Baring of the lamina cribrosa
 No12850 (39.1%)Reference0.02
 Yes35482 (23.2%)0.56 (0.34 to 0.92)
 Unknown942257 (27.3%)0.63 (0.40 to 1.00)
Baseline risk factors
Functional progression
Eyes, nEyes with moderate/fast functional progression, n, (%)Adjusted OR
(95% CI)†
P values
IOP (per 1 mm Hg increase)78957 (7.2%)1.05 (1.02 to 1.09)0.004
 TC509 (18.00%)Reference
 TT42219 (4.50%)0.21 (0.08 to 0.59)0.003
 TC323 (9.38%)Reference
 TT28526 (9.12%)1.00 (0.26 to 3.89)1.00
  • *From the multivariable logistic regression model that included baseline RNFL thickness and baring of the lamina cribrosa as predictors, and fast structural progression in RNFL (yes/no) as the outcome variable.

  • †From the multivariable logistic regression model that included baseline IOP and interaction term between TRIM66 and gender as predictors, and moderate/fast functional progression in mean deviation as the outcome variable. The analyses were restricted to 789 eyes with data on baseline IOP and TRIM66. The interaction between TRIM66 and gender was 0.01.

  • RNFL, retinal nerve fibre layer; IOP, intraocular pressure.