Multivariable analyses of baseline risks factors for being a fast structural progressor and a moderate/fast functional progressor
| Baseline risk factors Structural progression | Eyes, n | Eyes with fast structural progression, n, (%) | Adjusted OR (95% CI)* | P value |
| RNFL (per 10 μm increase) | 1424 | 389 (27.3%) | 2.64 (2.34 to 2.98) | <0.0001 |
| Baring of the lamina cribrosa | ||||
| No | 128 | 50 (39.1%) | Reference | 0.02 |
| Yes | 354 | 82 (23.2%) | 0.56 (0.34 to 0.92) | |
| Unknown | 942 | 257 (27.3%) | 0.63 (0.40 to 1.00) | |
| Baseline risk factors Functional progression | Eyes, n | Eyes with moderate/fast functional progression, n, (%) | Adjusted OR (95% CI)† | P values |
| IOP (per 1 mm Hg increase) | 789 | 57 (7.2%) | 1.05 (1.02 to 1.09) | 0.004 |
| Female | ||||
| TRIM66 | ||||
| TC | 50 | 9 (18.00%) | Reference | |
| TT | 422 | 19 (4.50%) | 0.21 (0.08 to 0.59) | 0.003 |
| Male | ||||
| TRIM66 | ||||
| TC | 32 | 3 (9.38%) | Reference | |
| TT | 285 | 26 (9.12%) | 1.00 (0.26 to 3.89) | 1.00 |
*From the multivariable logistic regression model that included baseline RNFL thickness and baring of the lamina cribrosa as predictors, and fast structural progression in RNFL (yes/no) as the outcome variable.
†From the multivariable logistic regression model that included baseline IOP and interaction term between TRIM66 and gender as predictors, and moderate/fast functional progression in mean deviation as the outcome variable. The analyses were restricted to 789 eyes with data on baseline IOP and TRIM66. The interaction between TRIM66 and gender was 0.01.
RNFL, retinal nerve fibre layer; IOP, intraocular pressure.