Table 1

The demographic and clinical characteristics of the infants with type 1 ROP or aggressive ROP

ParametersInfants with type 1 ROP
(n=70, 131 eyes)		Infants with aggressive ROP
(n=24, 45 eyes)		P value
Gestational age, weeks25.7±1.825.2±2.00.2311
Birth weight, g832.01±274.84824.21±311.870.9079
ROP zone at primary treatment, eyes
 Zone I18 eyes20 eyes<0.0001*
 Posterior zone II34 eyes6 eyes
 Zone II79 eyes19 eyes
PMA at primary treatment, weeks38.3±6.135.6±3.40.0003*
Primary treatment choice, eyes
 Anti-VEGF injection monotherapy97 eyes40 eyes0.1075
 Laser ablation monotherapy32 eyes5 eyes
 Combination (anti-VEGF+laser treatment)2 eyesnone
 Time of plus disease disappearance after primary treatment, days17.9±16.3 ~ not disappear28.7±14.1 ~ not disappear0.0467*
Additional treatment-requiring eyes35 eyes (26.72%)25 eyes (55.56%)0.0004*

  • Values of gestational age, birth weight, PMA at primary treatment and periods of plus disease disappearance in each group are presented as mean±SD.

  • *Statistically significant by the Pearson’s χ2 test or Fisher’s exact test.

  • anti-VEGF, antivascular endothelial growth factor.PMA, postmenstrual age; ROP, retinopathy of prematurity;