Regression analysis of blood pressure parameters and measures of blood pressure variability with clinical outcomes of 20/200 or worse vision, increase in Snellen lines of visual acuity, worsening logMAR vision and macular redetachment status at POM6, adjusted for preoperative level of detachment and type of anaesthesia used
Risk factor | Visual acuity of 20/200 or worse at POM6 | Increased snellen lines of improvement at POM6 | Worsening logMAR visual acuity at POM6 | Macular redetachment at POM6 |
Higher preoperative MAP | 0.013 | −0.054** | 0.010† | 0.007 |
Higher mean intraoperative SBP | 0.034* | −0.024† | 0.011* | 0.018 |
Higher mean intraoperative DBP | 0.053* | −0.040 | 0.017 | 0.033 |
Higher mean intraoperative MAP | 0.054* | −0.043† | 0.018* | 0.032 |
Higher intraoperative SD of SBP | 0.100* | −0.083* | 0.035* | −0.004 |
Higher intraoperative SD of DBP | 0.126 | −0.126 | 0.048 | −0.109 |
Higher intraoperative SD of MAP | 0.121† | −0.124* | 0.046 | −0.027 |
Notes: Risk factors are shown in rows and outcomes are shown in columns. The value of coefficients indicate a stronger association (for positive values) or reverse association (negative value) with the outcomes. The marker next to each coefficient indicates its statistical significance, and also conveys the uncertainty in the association relative to its strength. Coefficients with p<0.05 are highlighted with darker border and cell shading. The largest absolute value of the coefficients with the smallest p values, therefore, indicate the strongest and least noisy associations.
Coefficients were obtained using generalised estimating equations considering each patient as a cluster. All analyses were performed on 71 eyes (57 patients), except when using preoperative MAP where there were 68 eyes (55 patients).
*p<0.05, **p<0.01.
†p<0.10.
DBP, diastolic blood pressure; MAP, mean arterial pressure; POM6, postoperative month 6; SBP, systolic blood pressure.